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An unconscious defense mechanism used to allay anxiety by denying the existence of important conflicts, troublesome impulses, events, actions, or illness.
Synonym(s): negation
[M.E., fr, O.Fr., fr. L. denegare, to say no]


A denial, contradiction, or negative statement.


An unconscious defense mechanism used to allay anxiety by denying the existence of important conflicts or troublesome impulses.
Synonym(s): negation.
[M.E., fr, O.Fr., fr. L. denego, to say no]

Patient discussion about negation

Q. is her2 positive more agressive than her2 negative? i know someone with her2 positive breast cancer and her doctor said it was more difficult to detect upon its return if it came back i want to know if it is true and what can she do to detect it earlier

A. Over-expression of her2/neu, a specific molecule in the breast cancer cell is indeed considered to convey worse prognosis, and suggest the need for chemotherapy and immunotherapy with Herceptin. However, the decision is much more complicated and should be made on case by case basis after consulting a professional.

Q. Rising PSA to 10 with two negative biospies? Expect cancer? 67 yrs old in good health otherwise.

A. High values don't always mean it's cancer. At 67 years old, you're prostate is most likely enlarging, resulting in the higher PSA results. And after two negative biopsies, it sounds like you're in the clear. Like Brandon said though, keep up with your regular check ups.

Q. Does the cooking have a negative effect on the protein content of the food? I have heard that high temperatures cooking breaks the protein, so does the cooking have a negative effect on the protein content of the food?

A. Yes. Proteins can be denatured by heat, but only when the protein structure is delicate or is exposed to extremely high temperatures for long time. You must remember that breaking of protein is the physical-chemical process where the physical or chemical structure of a protein is rearranged. So cooking will not reduce on the nutritive value of the food until it’s cooked at cooking temperatures.

More discussions about negation
References in classic literature ?
But in the case of affirmation and negation, whether the subject exists or not, one is always false and the other true.
It was perhaps this negation in the Doctor which made his neighbors call him hard-headed and dry-witted; conditions of texture which were also held favorable to the storing of judgments connected with drugs.
Taken for what it is worth, the expression of this mood--the culture of ennui for its own sake--is certainly carried to its ideal of negation by Amiel.
In all ordinary matters of sentiment I am simply a negation.
She shook her head in curt negation while, caked in mud and inexpressibly serious-faced, Fyne seemed to be backing her up with all the weight of his solemn presence.
But if there be anything which is of such a nature as to be and not to be, that will have a place intermediate between pure being and the absolute negation of being?
Being is the vast affirmative, excluding negation, self-balanced, and swallowing up all relations, parts and times within itself.
Why is there so much negation and abnegation in your hearts?
In former days," said Golenishtchev, not observing, or not willing to observe, that both Anna and Vronsky wanted to speak, "in former days the free-thinker was a man who had been brought up in ideas of religion, law, and morality, and only through conflict and struggle came to free-thought; but now there has sprung up a new type of born free-thinkers who grow up without even having heard of principles of morality or of religion, of the existence of authorities, who grow up directly in ideas of negation in everything, that is to say, savages.
To the sentiment of being alone of one's kind, to the clear perception of the loneliness of one's thoughts, of one's sensations--to the negation of the habitual, which is safe, there is added the affirmation of the unusual, which is dangerous; a suggestion of things vague, uncontrollable, and repulsive, whose discomposing intrusion excites the imagination and tries the civilized nerves of the foolish and the wise alike.
He's without as much faith as is necessary for complete negation, and without that much law as is implied in lawlessness.
Razumov's presence in Geneva, a little more credible--for this is a Russian story for Western ears, which, as I have observed already, are not attuned to certain tones of cynicism and cruelty, of moral negation, and even of moral distress already silenced at our end of Europe.