nedocromil sodium


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Related to nedocromil sodium: imipramine, cromolyn sodium, Tilade

nedocromil sodium

the sodium salt of nedocromil, administered topically to the conjunctiva in the treatment of allergic conjunctivitis.

mast cell stabilizers

Prophylactic drugs used to treat allergic conjunctivitis, vernal conjunctivitis, giant pupillary conjunctivitis, superior limbic keratoconjunctivitis. They act by stabilizing the membranes of mast cells thus preventing the release of histamine. Common agents are sodium cromoglicate (cromolyn sodium), lodoxamide, nedocromil sodium, olopatadine hydrochloride and pemirolast potassium. See antihistamine; hypersensitivity.

nedocromil sodium (ned´ōkrō´mil),

n brand name: Tilade;
drug class: antiasthmatic, mast cell stabilizer;
action: stabilizes the membrane of the sensitized mast cell, preventing release of chemical mediators after an antigen-IgE interaction;
use: prophylaxis only in reversible obstructive airway diseases such as asthma.
References in periodicals archive ?
Nedocromil sodium has also been shown to be of potential use in reducing high-dose inhaled steroid use.
When nedocromil sodium in a four-times-daily dose was added to current therapy in stable, mild asthmatic children in placebo comparisons, there was significant improvement in daily peak expiratory flow and a reduction in daily bronchodilator use.
Jones P and the Nedocromil Sodium Quality of Life Study Group.
Cromolyn sodium and nedocromil sodium are non-steroidal treatments that may also be inhaled and used as "controller" medication rather than for treating symptoms once they've developed.
ALOCRIL(TM) is administered in a sterile, topical solution containing 2% nedocromil sodium.
In an environmental study (N = 79), 37 percent of the subjects participating reported experiencing relief from symptoms within two minutes of applying nedocromil sodium ophthalmic solution 2% topically; fully 77 percent achieved control over their symptoms within 15 minutes.
Nedocromil Sodium - Nedocromil is marketed as Tilade in an MDI formulation.
Although inhaled corticosteroids are first-line anti-inflammatory agents and acceptable for primary therapy of moderate asthma in children, the antiasthmatic prophylactic agents cromolyn sodium, nedocromil sodium, and leukotriene modifiers may be used as an initial choice for long-term control therapy in mild persistent asthma (step 2 therapy) with children, because these medications have excellent safety profiles.
In addition to the opening, Rhone-Poulenc Rorer announced that it would be taking an option on an adjacent 4-hectare plot and would also be investing US$15 million in the first and original facility at the site (completed in 1993) to create a dual purpose plant for nedocromil sodium and sodium cromoglycate.
Bernard Dubois, president of Worldwide Industrial Operations for Rhone-Poulenc Rorer, commented that, "the opening of this new facility along with further investment to improve the flexibility of the nedocromil sodium plant and our commitment to the adjacent 4-hectares sends a clear message of our long-term commitment to Singapore as a manufacturing base for active pharmaceutical ingredients.
Later, the alliance will expand to include Fisons' Opticrom(R) (4 percent cromolyn sodium ophthalmic solution, USP) and nedocromil sodium ophthalmic solution.
Fisons and Allergan will also co-develop and co-promote Fisons' nedocromil sodium ophthalmic solution, which will be launched in the U.