In some cases there are areas of frank vasculitis of medium-sized vessels characterized by transmural necrotizing inflammation
with variable giant cells (Figure 3, C).
Definitive diagnosis is by histopathologic evidence of necrotizing inflammation
of the medium and small-sized arteries.
First multiple skin biopsy was done to rule out skin malignancy and fortunately the pathology was ulcer with acute necrotizing inflammation
Polyarteritis nodosa (PAN) is a disorder characterized by necrotizing inflammation of the small- or medium-sized muscular arteries, commonly within the kidneys, gastrointestinal (GI) tract, skin, nerves, joints, and the muscles (1).
The conventional mesenteric angiography confirming total occlusion of the inferior mesenteric artery and necrotizing inflammation of the muscular arteries of the colonic wall on the pathological examination clarified the diagnosis of PAN.
Polyarteritis nodosa (PAN) is an uncommon systemic vasculitis characterized by necrotizing inflammation
of small- or medium-sized arteries.
Histologic examination of the nodes demonstrated granulomatous and partly necrotizing inflammation
The symptoms do not fit the typical picture of necrotizing inflammation
of the caecum typhlitis seen in leukemia patients (Lancet 355:281-83, 2000).