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necrolysis

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necrolysis /ne·crol·y·sis/ (nĕ-krol´ĭ-sis) separation or exfoliation of necrotic tissue.
toxic epidermal necrolysis  a severe cutaneous reaction, primarily to drugs, but also due to other causes such as infections or neoplastic disease, characterized by bulla formation, subepidermal separation, and widespread loss of skin, leaving raw denuded areas.

ne·crol·y·sis (n-krl-ss)
n.
Necrosis and loosening of tissue.

necrolysis
[nekrol′isis]
Etymology: Gk, nekros + lysis, loosening
disintegration or exfoliation of dead tissue. Compare necrosis. necrolytic, adj.

necrolysis [nĕ-krol´ĭ-sis]
separation or exfoliation of necrotic tissue.
toxic epidermal necrolysis an exfoliative skin disease in which erythema spreads rapidly over the body, followed by blisters much like those seen in a second degree burn. It may be caused by drug reactions, infections (viral, bacterial, or fungal), neoplastic disease, graft-versus-host reaction, and chemical exposure.

necrolysis
separation or exfoliation of necrotic tissue.

toxic epidermal necrolysis
an acute exfoliative disease of skin and mucous membranes in dogs, cats and monkeys. Characterized by full thickness epidermal necrosis and accompanied by erythema, vesicles, bullae and ulcers, and systemic signs of fever, anorexia and lethargy. It is associated with concurrent infections or neoplasia, and drug reactions.


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Viard I, Wehrli P, Bullani R et al: Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
Cases of carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported among carriers of this allele (Pharmacogenomics 2008; 9: 1543-6).
Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a review of 10 years' experience.
 
 
 
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