necrobiotic xanthogranuloma


Also found in: Acronyms.

nec·ro·bi·ot·ic xan·tho·gran·u·lo·ma

a cutaneous and subcutaneous xanthogranuloma with focal necrosis, presenting as multiple large, sometimes ulcerated, red to yellow granulomatous nodules with giant cells (often around the eyes) associated with paraproteinemia (usually monoclonal gammopathy).
References in periodicals archive ?
Orbital necrobiotic xanthogranuloma associated with systemic IgG4 disease.
After a 25-year course of necrobiotic xanthogranuloma with paraproteinemia, this patient died of bacteremia following pancytopenia as he developed myeloma, Dr.
Necrobiotic xanthogranuloma is characterized by the presence of subcutaneous skin lesions that tend to ulcerate and become fibrotic.
When AOXGD presents with monoclonal gammopathy, as in cases of necrobiotic xanthogranuloma or in rare occasions, AAPOX, it needs to be differentiated from multiple myeloma with involvement of the orbit or plasmacytoma of the eye and/or of the orbit.