Also found in: Dictionary, Thesaurus, Encyclopedia.


Pertaining to or characterized by necrobiosis.


Pertaining to or characterized by necrobiosis.


(nek-ro-bi-o'sis) [? + biosis, life]
Gradual degeneration and swelling of collagen bundles in the dermis. See: necrosisnecrobiotic (ne?kro-bi-ot'ik), adjective

necrobiosis lipoidica diabeticorum

A skin disease marked by necrotic atrophy of connective and elastic tissue. The lesions have a central yellowish area surrounded by a brownish border and telangiectases and usually present on the anterior surface of the legs. The disease is commonly found in people who have had diabetes mellitus for many years. Beginning as 1 to 3 mm papules or nodules, the lesions enlarge to become waxy or shiny round plaques that are reddish brown at first and later become yellow atrophic lesions. Synonym: diabetic dermopathy

Patient care

Infection and, occasionally, ulceration result when an affected area is traumatized. A variety of treatments have been tried for patients who find the rash unsightly; none are definitively effective. The patient also should be taught methods for protecting legs and other affected areas from injury. Graduated compression stockings should be worn, and the legs should be rested frequently.

References in periodicals archive ?
After a chapter on the structure and function of skin, volume one covers disorders of keratinization; inherited and autoimmune subepidermal blistering diseases; acantholytic disorders; spongiotic, psoriasiform, and pustular dermatoses; superficial and deep perivascular inflammatory dermatoses; granulomatous, necrobiotic, and perforating dermatoses; inflammatory diseases of the subcutaneous fat; diseases of the oral mucosa; diseases of the genital skin; degenerative and metabolic diseases; cutaneous adverse reactions to drugs; neutrophilic and eosinophilic dermatoses; vascular diseases; idiopathic connective tissue disorders; and infectious diseases of the skin.
The exact relation between granuloma annulare and diabetes, necrobiotic granuloma, and rheumatoid nodules has been debated (24, 25).
Evans CS, Goldman RL, Klein HZ, et al: Necrobiotic granulomas of the uterine cervix.
Microscopy findings included signs of focal encephalitis and vasculitis, lymphocytic perivascular inflammatory infiltration, profound degenerative and necrobiotic changes of ganglion cells in the cerebral cortex, and signs of brain edema, as well as parenchymal myocarditis (stromal edema, degeneration of myocytes, foci of myolysis, and fragmentation of myofibrils).
It consists of seventeen Arabic star names expanded like acronyms into short, acrostic aphorisms (for example, Gienah becomes "Gide, in extremis, necrobiotic, Almost hegelian").
These necrobiotic nodules are often located subpleurally and surrounded by palisading histiocytes and giant cells.