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the physiologic death of cells; a normal mechanism in the constant turnover of many cell populations. Called also bionecrosis. adj., adj necrobiot´ic.
necrobiosis lipoi´dica a dermatosis characterized by patchy degeneration of the elastic and connective tissue of the skin with degenerated collagen occurring in irregular patches, especially in the dermis, most often on the mid or lower shins; usually associated with diabetes.
nec·ro·bi·o·sis li·poi·d'i·ca, necrobiosis lipoidica diabeticorum
a condition, in many cases associated with diabetes, in which one or more yellow, atrophic, shiny lesions develop on the legs (typically pretibial); characterized histologically by indistinct areas of necrosis in the cutis.
Etymology: Gk, nekros, dead, bios, life, lipos, fat, eidos, form
a skin disease characterized by thin, shiny, yellow-to-red plaques on the shins or forearms. Telangiectases and crusting and ulceration of these plaques may occur. Necrobiosis lipoidica is usually associated with diabetes mellitus and occurs most often in women. Treatment includes precise control of the diabetes and, possibly, intralesional application of corticosteroids.
necrobiosis lipoidicaAn inflammatory dermatosis that is most common in diabetics (75% of cases), usually on the legs. In 10% of patients, it precedes the onset of diabetes. It is less commonly associated with inflammatory bowel disease, rheumatoid arthritis, and thyroid disease.
necrobiosis lipoidicaDermatology An inflammatory condition seen in 50-80% of DM, most often on the legs; in 10%, NL precedes onset of DM. See Non-insulin-dependent diabetes mellitus.
nec·ro·bi·o·sis li·poi·di·ca, necrobiosis lipoidica diabeticorum (nek'rō-bī-ō'sis li-poyd'i-kă, dī-ă-bet'i-kōr'ŭm)
A condition often associated with diabetes, in which one or more yellow, atrophic lesions develop on the legs.