natural immunity


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Related to natural immunity: acquired immunity

in·nate im·mu·ni·ty

resistance manifested by a species (or by races, families, and individuals in a species) that has not been immunized (sensitized, allergized) by previous infection or vaccination; much of it results from body mechanisms that are poorly understood but differ from those responsible for the altered reactivity associated with the specific nature of acquired immunity; in general, innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self.

natural immunity

a usually inherent, nonspecific form of immunity to a specific disease. Kinds of natural immunity include individual immunity, racial immunity, and species immunity. Also called genetic immunity, innate immunity. Compare acquired immunity. See also active immunity, passive immunity.

in·nate im·mu·ni·ty

(i-nāt' i-myū'ni-tē)
Resistance manifested by an organism that has not been sensitized by previous infection or vaccination; innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self
Synonym(s): natural immunity, nonspecific immunity.

natural immunity

The ability to resist infection that does not depend on prior experience of the invading organism and the resultant production of antibodies or amendment or selection of LYMPHOCYTES. Natural immunity is a general and non-specific resistance to infection possessed by all healthy individuals. Also known as natural resistance.

natural immunity

immunity due to the possession of suitable genetical characteristics rather than immunity produced in response to a vaccine or serum.

immunity

1. the condition of being immune; security against a particular disease; nonsusceptibility to the invasive or pathogenic effects of microorganisms or helminth parasites or to the toxic effect of antigenic substances. Called also functional or protective immunity.
2. responsiveness to antigen that leads to more rapid binding or elimination of antigen than in the nonimmune state; it includes both humoral and cell-mediated immunity (below).
3. the capacity to distinguish foreign material from self, and to neutralize, eliminate or metabolize that which is foreign (non-self) by the physiological mechanisms of the immune response.
The mechanisms of immunity are essentially concerned with the body's ability to recognize and dispose of substances which it interprets as foreign and sometimes harmful to its well-being. When such a substance enters the body, complex chemical and mechanical activities are set into motion to defend and protect the body's cells and tissues. The foreign substance, usually a protein, is called an antigen, that is, one which generates the production of an antagonist. The most readily recognized response to the antigen is the production of antibody. The antigen-antibody reaction is an essential component of the overall immune response. Of equal or greater importance to antibody, particularly for some antigens, is the development of so-called cell-mediated immune response, which involves clonal expansion of specifically reactive T lymphocytes including cytotoxic T lymphocytes (Tc lymphocytes) which play a major role in eliminating the foreign antigens that are cell associated.
Immunological responses in animals can be divided into two broad categories: humoral immunity, which refers to the production of antibody which becomes part of the body fluids (humors), especially serum, and cell-mediated or cellular immunity, which involves a variety of activities designed to destroy or at least contain cells that are recognized by the body as expressing foreign antigens on their cell surface, e.g. viral antigens. Both types of response are mediated by lymphocytes that originate in the bone marrow as stem cells and later are converted into mature cells having specific properties and functions.

acquired immunity
antigen specific immunity attributable to the production of antibody and of specific immune T lymphocytes (responsible for cell-mediated immunity), following exposure to an antigen, or passive transfer of antibody or immune lymphoid cells (adoptive immunity).
active immunity
that which follows exposure to an antigen; acquired immunity attributable to the presence of antibody or of immune lymphoid cells formed in response to antigenic stimulus. Called also adaptive immunity.
adoptive immunity
passive immunity of the cell-mediated type conferred by the administration of sensitized lymphocytes from an immune donor to a naive recipient.
artificial immunity
includes acquired (active) immunity produced by deliberate exposure to an antigen, such as a vaccine or the administration of antibody (passive).
cellular immunity
dependent upon T lymphocytes which are sensitized by first exposure to a specific antigen. Subsequent exposure stimulates the release of a group of substances known as lymphokines, such as interferon, and interleukins as well as direct killing by cytotoxic T lymphocytes.
functional immunity
see immunity (above).
humoral immunity
mediated by antibodies formed by antigen-specific B lymphocytes. Each B lymphocyte has monomeric IgM receptors which capture specific antigen, initiating production of the specific immunoglobulins. B lymphocytes activated by the presence of their specific antigen undergo transformation, lymphocyte blastogenesis, whereby they become metabolically active, divide, and some mature to plasma cells, which are major producers of antibodies. Some cells revert to small lymphocytes, 'memory' cells, and the expanded clone of these cells, on re-exposure to the antigen, undergo further lymphocyte blastogenesis, leading to further increased antibody production and numbers of memory cells.
There are two types of humoral immune response: primary and secondary. The primary response begins immediately after the inital contact with an antigen; the resulting antibody, predominantly IgM, appears 48 to 72 hours later. The secondary response occurs within 24 to 48 hours and produces large quantities of predominantly IgG. The secondary response persists much longer than the primary response and is the result of repeated contact with the antigens.
innate immunity, native immunity, natural immunity
natural immunity resulting from the genetic makeup of the host, before exposure to an antigen.
maternal immunity
that acquired by the neonate by transplacental transfer of immunoglobulins or from ingestion of colostrum or via the yolk sac in the case of birds. The placentation of all agricultural animals precludes trans-placental transfer of immunoglobulin. Passive transfer of maternal immunity is effected by the transfer of immunoglobulilns present in high concentration in the first milk, colostrum, through the intestine of the newborn. The success of this transfer is dependent upon the time after birth that colostrum is ingested (physiologically 24-36 hours, but effectively for adequate transfer, 8 hours after birth) and on the mass of immunoglobulin ingested which is determined by the concentration of immunoglobulin in colostrum and the amount of colostrum ingested.
Failure of passive transfer results in a significant increase in risk for neonatal disease. Neonates that fail to acquire serum concentrations of IgG1 greater than 10 mg/ml are at significantly higher risk of septicemic, enteric and respiratory disease. Failure of passive transfer occurs as a result of neonates sucking the dam or acquiring colostrum by artificial feeding too late in the absorptive process, or by receiving too little colostrum or receiving colostrum with low immunoglobulin concentration. See also passive immunity (below) and colostral immunoglobulin.
natural immunity
see innate immunity (above).
passive immunity
the transfer of antibodies from a donor in which they were produced to a recipient for temporary immunity. Can be in the form of serum or colostrum or yolk. Significant transplacental transfer of antibodies is found in primates, but does not occur in domestic animals. Passive immunity in domestic mammals comes via the colostrum, with its high concentration of antibodies, and the more than normally pervious epithelium of the neonate's intestinal epithelium. In birds maternal antibody is transferred to the yolk, from where the developing chick embryo absorbs it from about day 11 of incubation. See also passive immunization.
protective immunity
see immunity (above).
References in periodicals archive ?
When new influenza viruses are introduced into the environment, humans do not have any natural immunity to protect against them.
Writing in an accessible, humorous style, he combines the latest scientific findings on disease prevention and treatment with the age-old wisdom of Mom and Grandma, explaining germs and germ routes, the body's natural immunity, and weapons in the war against germs: antibiotics, antivirals, antifungals, antiparasitics, and vaccines.
Fast-forwarding three years, military virologist Robert Neville (Smith) - one of the lucky few with natural immunity to the contagion - leads a highly regimented life with his dog Sam in the ruins of the Big Apple.
1) Improve your defence--influenza immunisation improves you body's natural immunity.
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Tokyo, Japan, June 13, 2006 - (JCN) - Tohoku University's Graduate School of Pharmaceutical Sciences has elucidated the roles of peptidoglycan recognition protein (PGRP)-LE in natural immunity in collaboration with the University of Massachusetts Medical School.
And because people have no natural immunity to the virus, health experts say healthy adults are also susceptible to becoming seriously ill.
The] secular system al lows homosexuality [and] the loss of natural immunity, like AIDS.
Bringing together so many people from every corner of the world can expose British people to new viruses and illnesses, such as meningitis, for which they have little natural immunity.
Some antibodies play key roles in fostering this natural immunity.
The doctors induced a temporary coma and treated her with antiviral drugs to boost her immune system and allow her natural immunity to fight the virus.