natriuretic peptide


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Related to natriuretic peptide: natriuretic peptide B

a·tri·al na·tri·u·ret·ic pep·tide (ANP),

a 28-amino acid peptide (α-ANP) derived from cardiac atria, several smaller fragments of α-ANP, and a dimer of α-ANP with 56 amino acids (β-ANP) that are present in plasma in heart failure. Among other actions, ANP promotes renal salt and water excretion, increases capillary function, and decreases arterial pressure and the secretion of renin, angiotensin, aldosterone, and antidiuretic hormone.

natriuretic peptide

Any peptide that stimulates the kidneys to excrete salt and water.
See also: peptide

natriuretic peptide

A PEPTIDE present in the blood and raised in quantity in people with long-term (chronic) HEART FAILURE. It arises in the upper chambers of the heart, probably as a result of stretching, and causes blood vessels to widen and the output of urine to increase. By increasing output of urinary sodium and, with it, water, it helps to relieve the OEDEMA that is a feature of HEART FAILURE. Also known as atrial natriuretic factor. B-type natriuretic peptide is released by ventricular muscle cells and is used as a therapeutic agent in heart failure. It is also used as a biomarker for differential diagnosis of breathlessness and for preclinical assessment of heart failure.
References in periodicals archive ?
USA], August 26 ( ANI ): Recent research shows that elevated levels of natriuretic peptides in adipose tissue protect against effects of high-fat diet.
The receptors, termed natriuretic peptide receptors (NPRs) are classified as types A and B.
Natriuretic peptide levels were similar in patients with normal diastolic function (n=16; NT-proBNP: median, 168 pmol/L; interquartile range, 118 to 289 pmol/L), an impaired relaxation pattern (n=24; NT-proBNP: median, 269 pmol/L; interquartile range, 164 to 778 pmol/L) or a pseudonormal pattern (n=5; NT-proBNP: median, 846 pmol/L; interquartile range, 398 to 2867 pmol/L).
Blood N-terminal pro-brain natriuretic peptide levels were higher in cases than the controls (pless than 0.
The company added that the US Patent 8,580,747, entitled 'Cyclic Natriuretic Peptide Constructs,' has composition of matter claims relating to its PL-3994 natriuretic peptide receptor-A agonist for treatment of cardiovascular and pulmonary indications.
Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.
It was observed that the level of brain natriuretic peptide was not related to body weight (Graphic 1; p = 0.
Nile is initially focusing its efforts on developing its lead compound, cenderitide, a novel, rationally designed chimeric peptide for the treatment of heart failure, and CU-NP, a second novel, rationally designed natriuretic peptide.
Plasma levels of B-type natriuretic peptide (BNP) "had predictive utility for death, heart failure, and MI, even when adjusted for risk factors and structural abnormalities" of the heart in the general population, Dr.
BNP is a more robust prognostic marker than atrial natriuretic peptide in the general population without heart failure," Dr.