naringin


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naringin

(nar'i-jin),
A bioflavonoid responsible for the bitter taste in grapefruit.
[Sansk. naringa, orange tree, + -in]

naringin

A flavanone glycoside and major flavonoid in grapefruit, which gives grapefruit juice its tangy/bitter taste. Naringin is metabolised in vivo to the flavanone naringenin.
 
Health benefits
Antioxidant activity; lowers serum lipid levels.

Alleged health benefits
Reduced risk of cancer; reduced neurologic residua following stroke.

Pharmacologic effects
Naringin inhibits certain cytochrome P450 enzymes (e.g., CYP3A4 and CYP1A2); it also inhibits vascular endothelial growth factor (VEGF) release, which induces angiogenesis.
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References in periodicals archive ?
Naringin and sertraline ameliorate doxorubicin-induced behavioral deficits through modulation of serotonin level and mitochondrial complexes protection pathway in rat hippocampus.
In addition, fermentation parameters are not affected by naringin and quercetin [4], consistent with the results of this study.
Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice.
18] reported that naringin and hesperidin reduced the cholesterol and triglyceride levels significantly by inhibiting HMG-CoA reductase and acetyl-coenzyme A acetyltransferase.
Flavanoids in grapefruit, such as naringin, inhibit OATPs, which is competitive in nature.
The use of citrus bioflavonoids, which include rutin, quercetin, hesperidin, and naringin, has shown clinical results in the treatment of capillary permeability associated with allergic rhinitis.
Standardly catechin (CA) naringin (NA) rutin (RU) resveratrol (RES) myricetin (MIR) morin (MOR) naringenin (NAR) quercetin (QU) and kaempferol (KA) mixture was used.
The researchers gave one group of mice naringin, a bioactive compound in grapefruit juice that has been identified as a key agent in weight loss, and another group metformin, a glucose-lowering drug often prescribed for those with Type 2 diabetes.
Meanwhile, oranges are rich in several antioxidants, including hesperidin, naringin and tangeretin, which studies show may help to lower blood cholesterol.
Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice.
Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats.
1) Immensely rich in hesperidin and naringin, oranges are emerging as a weapon for boosting eye health, fighting heart disease, preventing kidney stones, and enhancing immunity.