nanolipogel

nanolipogel

A drug-delivery system consisting of nanoscale, hollow spheres made of a biodegradable, FDA-approved synthetic lipid, which can be loaded with an array of molecules. In early feasibility studies on melanomas, nanolipogel microspheres were loaded with transforming growth factor-beta and interleukin-2, and were biodegraded in vivo, resulting in neutralisation of the melanoma’s secretions and upregulation of the patient’s immune response.
References in periodicals archive ?
The novel nanolipogel delivery system we used will hopefully bypass systemic toxicities while providing support to enable the body to fight off the tumour at the tumour bed itself.
Each nanolipogel is small enough to travel through the bloodstream, but large enough to get entrapped in leaky cancer blood vessels.
At the same time, the spheres - called nanolipogels - release a protein that rallies the body's defences.
The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed.
We do that using the inhibitor that is released from the nanolipogels.
The tiny hollow spheres, called nanolipogels (NLGs), become trapped in leaky tumour blood vessels, where they unleash an anti-cancer drug.