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naltrexone hydrochloride

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naltrexone hydrochloride
[naltrek′sōn]
an oral opioid antagonist.
indications It is prescribed to block the effects of opioid analgesics, including heroin, morphine, and methadone in patients recovering from addiction, and to treat ethanol dependence.
contraindications Acute hepatitis or liver failure prohibits its use. Periodic liver function tests are recommended for all patients. Patients must be completely free of opioids before taking naltrexone to prevent severe withdrawal symptoms. Patients must be educated that their tolerance to morphine disappears while they are on naltrexone and that they can be much more sensitive to opioids after discontinuing naltrexone; past dosages of heroin, morphine, etc., could now be fatal.
adverse effects The most serious adverse effects are abdominal pain, cramps, nausea, vomiting, headache, sleep disorders, and joint and muscle pain. Some adverse effects may actually be withdrawal symptoms rather than reactions to naltrexone.


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It was demonstrated in single dose studies for ELI-216 that no quantifiable blood levels of naltrexone hydrochloride were released at a limit of quantification ("LOQ") of 7.
The study also helped determine the appropriate levels of naltrexone hydrochloride required to reduce or eliminate the euphoria experienced by subjects who might take crushed product to achieve a "high".
ELI-216 is a controlled-release oxycodone hydrochloride agonist combined with an opioid antagonist, naltrexone hydrochloride, formulated to deter abuse of the drug.
 
 
 
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