naltrexone


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naltrexone

 [nal-trek´sōn]
an opioid antagonist used as the hydrochloride salt in treatment of opioid or alcohol abuse.

nal·trex·one

(nal-treks'ōn),
An orally active narcotic antagonist; devoid of pharmacologic action when administered in the absence of narcotics.

naltrexone

/nal·trex·one/ (nal-trek´sōn) an opioid antagonist used as the hydrochloride salt in treatment of opioid or alcohol abuse.

naltrexone

(năl-trĕk′sōn)
n.
A synthetic opioid antagonist, C20H23NO4, used in its hydrochloride form to treat addiction to alcohol and to opioid drugs such as heroin.

naltrexone

Substance abuse An opioid antagonist used to manage opiate, alcohol and other abuse substances; naltrexone binds to endorphin receptors, preventing endophin receptor binding, reducing the craving for abuse substances. See Cocaine. Cf Antabuse.

naltrexone

A narcotic antagonist used as a maintenance therapy in former narcotic addicts. A brand name is Nalorex.

naltrexone (nal·trekˑ·sōn),

n a pharmacologic substance that increases the body's production of endorphins; used in treating narcotic addiction.

nal·trex·one

(nal-treks'ōn)
Orally active narcotic antagonist; devoid of pharmacologic action when administered in absence of narcotics.

naltrexone

an opiate antagonist similar to naloxone but with longer action and greater potency.
References in periodicals archive ?
Naltrexone, an opioid receptor antagonist, is effective in treating both AUD and opioid use disorder.
B is maintained on naltrexone, 50 mg/d, for 2 months.
In two subsequent reports by some of the same authors, pregnancy outcomes in 9 and 17 heroin users with naltrexone implants were unremarkable and comparable to those of women on methadone maintenance therapy.
During detoxification, substitute opioids were given to both groups along with other medication and gradually tapered off and stopped after 1-2 weeks so that after 2 weeks all patients were started on Naltrexone 50mg/day.
Following oral administration, naltrexone undergoes rapid and nearly complete absorption with approximately 96% of the dose absorbed from the gastrointestinal tract.
Twenty-two were placebo-controlled for acamprosate (1000-3000 mg/d), 44 for naltrexone (50 mg/d oral, 100 mg/d oral, or injectable) and 4 compared the 2 drugs.
In another study, the COMBINE trial, which found a "robust" effect of treatment with naltrexone over placebo among those with the Asp40 allele, "naltrexone seemed to be moderated by the presence of the Asp40 allele," with "essentially no effect" of naltrex one in the homozygous (Asn40/Asn40) group, he noted (Arch.
Naltrexone treatment, in any form, is also very different from Methadone treatment in that Naltrexone is not addictive," said (http://finance.
The new meta-analysis combined findings from five other papers, comprising a total of 1,565 patients who received extended-release Naltrexone compared to other therapies for six months, among nearly 60,000 overall patients.
Arkfeld explained the therapeutic rationale for its use in fibromyalgia thusly: Fibromyalgia has been classified as a CNS sensitization syndrome mediated by proinflammatory cytokines, and naltrexone has been shown to suppress such centrally acting cytokines.
During the last decade, some studies have tried higher doses and intermittent administration of naltrexone and nalmefene.
Patients present for removal of naltrexone implants due to infection or irritation at the insertion site, naltrexone intolerance or the requirement for effective opioid analgesia for comorbid conditions.