nalidixic acid


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nalidixic acid

 [nal″ĭ-dik´sik]
a quinolone antibacterial agent, active against most gram-negative bacteria causing urinary tract infection including Escherichia coli, Klebsiella and Enterobacter species, and some Proteus species. Pseudomonas species are generally resistant.

nal·i·dix·ic ac·id

(nal-i-dik'sik as'id),
An orally effective antibacterial agent used in the treatment of genitourinary tract infections.

nalidixic acid

/nal·i·dix·ic ac·id/ (nal-ĭ-dik´sik) a synthetic antibacterial agent used in the treatment of genitourinary infections caused by gram-negative organisms.

nalidixic acid

(nā′lĭ-dĭk′sĭk)
n.
An antibacterial drug, C12H12N2O3, used to treat urinary tract infections caused by gram-negative bacteria.

nalidixic acid

[nal′idik′sik]
an antibacterial.
indications It is prescribed in the treatment of certain urinary tract infections.
contraindications Renal or hepatic insufficiency, a history of convulsive disorders, or known hypersensitivity to this drug prohibits its use. It should not be used in children less than 3 months of age and should be used with care in prepubertal children.
adverse effects Quinolones have caused tendon rupture, especially in prepubertal children, and severe hypersensitivity reactions. Among the more serious effects are increased intracranial pressure, seizures, hemolytic anemia in people affected with glucose-6-phosphate dehydrogenase deficiency, and GI and neurological disturbances.

nalidixic acid

Antibiotics An early generation quinolone with a limited antimicrobial palate, primarily used for UTIs. See Quinolone.

nalidixic acid

A quinolone antibiotic drug, effective against GRAM NEGATIVE bacilli, including Proteus species, and much used for urinary infections. The drug is on the WHO official list. Brand names are Negram andUriben.

nal·i·dix·ic ac·id

(nali-diksik asid)
Orally effective antibacterial agent used to treat genitourinary tract infections.

nalidixic acid,

n an antibacterial prescribed in the treatment of urinary tract infections.

nalidixic acid

a naphthylidine derivative that inhibits DNA synthesis. Used for the treatment of urinary tract infections due to susceptible gram-negative bacteria. Side-effects in dogs include vomiting, diarrhea and seizures.
References in periodicals archive ?
Resistance was found in this study to nalidixic acid, a member of the drug class quinolones.
The standard antibiotic discs used in the study were Ampicillin, Gentamicin, Amikacin, Nalidixic acid, Norfloxacin, Ciprofloxacin.
Resistance was much higher--around 50% each--to the older, less-used agents ampicillin, nalidixic acid, and T/S.
The susceptibility of the urinary antiseptics, nalidixic acid and nitrofurantoin, is reported on isolates from urine samples.
Fluoroquinolones: Any of a group of broad-spectrum antibiotics derived from nalidixic acid
Meanwhile, another EU agency--the European Medicines Agency (EMEA)--has called for targeted research on increasing antimicrobial resistance within salmonella and campylobacter outbreaks to key antibiotic fluoroquinolones and related nalidixic acid (NOTE--SPELLING CHECKED).
7 were reports of animal studies; only 1 included any mention of ototoxicity, and it concerned mild inner ear toxicity that had been caused by nalidixic acid, which is a ciprofloxacin precursor.
Direct determination of nalidixic acid in urine by matrix isopotential synchronous fluorescence spectrometry.
These include naturally occurring molecules such as chiorophylls, porphyrins, phthalocyanines, flavins, thiazine dyes, acridine dyes, anthraquinone dyes, xanthene dyes, hypercin, tetracyclines, sulfanilamides, psoralens, nalidixic acid, coal tar derivatives, chlorpromazines and aminobenzoic acid derivatives, to name but a few.
Antibiotics were used at the following concentrations: nalidixic acid (nal) at 20 [micro]g/ml, ampicillin (amp) at 50 [micro]g/ml and streptomycin (str) at 25 [micro]/ml.
75 [micro]g), tetracycline (30 [micro]g), doxycycline (30 [micro]g), norfloxacin (5 [micro]g), ciprofloxacin (5 [micro]g), nalidixic acid (30 [micro]g), and erythromycin (30 [micro]g) (bioMerieux).