naked DNA


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A purified DNA sequence with no associated proteins. An immune response can be evoked by directly injecting into the host DNA that encodes an immunogen of interest

naked DNA

DNA that has been modified to remove the proteins that normally surround it. It is used for genetic transfers and vaccine manufacture.
See also: DNA
References in periodicals archive ?
Naked DNA delivery of angiogenic growth factors may be particularly attractive, since it provides prolonged production of the growth factor proteins at the site where they are needed, with a limited amount of protein escaping from that site.
Naked DNA is different from other gene delivery techniques because it doesn't use viruses to deliver the genetic material -- the genes are "virus-bare" or "naked.
In the Phase IIb trial for severe cardiovascular disease, VEGF- 2 is delivered to the ischemic tissue in the heart muscle in the form of naked DNA plasmid, a non-viral vector.
The patent, entitled Gene Therapy by Secretory Gland Expression, covers the delivery of naked DNA encoding any gene using either viral or non-viral vectors.
Senior Vice President of Science and Medical Affairs said, "Our compacted DNA nanoparticles robustly transfect post-mitotic human cells, achieving up to a 6,900-fold enhancement of gene expression compared to naked DNA.
In this first Phase II controlled challenge trial, the MuStDO 5 DNA vaccine will include dose escalation of a naked DNA agent encoding granulocyte macrophage colony stimulating factor (GM-CSF), an immune system stimulant.
NYSE:AVE), covering the use of Vical's naked DNA gene transfer technology to deliver a growth factor gene.
In comparison to vaccinations with naked DNA, the adenovirus-based vaccine showed a stronger anti-HIV immune response.
NYSE:AVE), rights to use Vical's naked DNA gene transfer technology to deliver a growth factor gene for which Aventis Pharma holds rights.
including a study in which a vaccine regimen employing Vical's patented naked DNA non-viral gene delivery technology was used in a prime-boost regimen with naked DNA plus adjuvant to prime and Merck's non-replicating adenoviral vector to boost.
Vical (NASDAQ:VICL) is also developing anticancer immunotherapeutics based on its naked DNA technology.
Vical's patented naked DNA technology is a biological method of delivering genes into cells in the body to cause production of desired proteins.