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nadolol |
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nadolol /na·do·lol/ (na-do´lol) a nonselective β used for the treatment of angina pectoris and hypertension.
nadolol [nad′ənol] a beta-adrenergic blocking agent. indications It is prescribed for long-term management of angina pectoris, for hypertension, and for migraine prophylaxis. contraindications Bronchial asthma, sinus bradycardia, greater than first-degree conduction block, cardiogenic shock, overt cardiac failure, or known hypersensitivity to this drug prohibits its use. adverse effects Among the more serious adverse effects are bronchospasm, bradycardia, precipitation of heart failure, cardiac arrhythmia, masking of signs of hypoglycemia in diabetics, fatigue, and lethargy. GI disturbances, rashes, and other allergic reactions may also occur. nadolol (nadō´lol), n brand name: Corgard; drug class: nonselective β-adrenergic blocker; action: competitively blocks stimulation of β-adrenergic receptors within the heart; produces negative chronotropic and inotropic activity, slows conduction of AV node, decreases heart rate, which decreases oxygen consumption in myocardium; also decreases activity of the renin-aldosterone-angiotensin system; uses: chronic stable angina pectoris, mild to moderate hypertension. nadolol an adrenergic blocking agent that affects both β1- and β2-receptors. nadolol Apo-Nadolol (CA), Corgard, Novo-Nadolol (CA), Syn-Nadolol (CA) Pharmacologic class: Beta-adrenergic blocker (nonselective) Therapeutic class: Antianginal, antihypertensive Pregnancy risk category C FDA Boxed Warning• Catecholamine hypersensitivity may occur after drug withdrawal. Angina exacerbation and in some cases, myocardial infarction have followed abrupt withdrawal. When discontinuing long-term nadolol, reduce dosage gradually over 1 to 2 weeks and monitor patient carefully. If angina worsens markedly or acute coronary insufficiency develops, reinstate drug promptly and take other appropriate measures to manage angina. Caution patient not to interrupt or stop therapy without physician's advice. Because coronary artery disease is common and may be unrecognized, don't discontinue drug abruptly, even in patients treated only for hypertension. ActionBlocks stimulation of beta1- and beta2-adrenergic receptor sites, decreasing cardiac output and thereby slowing heart rate and reducing blood pressure AvailabilityTablets: 20 mg, 40 mg, 80 mg, 120 mg, 160 mg ⊘Indications and dosages ➣ Angina pectoris Adults: Initially, 40 mg P.O. daily; may increase by 40 to 80 mg q 3 to 7 days p.r.n., up to a maximum of 240 mg/day ➣ Hypertension Adults: Initially, 40 mg P.O. daily; may increase by 40 to 80 mg q 7 days p.r.n., up to 320 mg/day Dosage adjustment• Renal impairment Off-label uses• Hyperthyroidism Contraindications• Hypersensitivity to drug or other beta-adrenergic blockers PrecautionsUse cautiously in: Administration• Give with or without food.
Adverse reactionsCNS: dizziness, fatigue, paresthesia, behavior changes, sedation CV: bradycardia, peripheral vascular insufficiency (Raynaud's phenomenon), heart failure EENT: blurred vision, dry eyes, nasal congestion GI: nausea, constipation, diarrhea, abdominal discomfort or bloating, indigestion, anorexia Respiratory: bronchospasm Skin: rash InteractionsDrug-drug. Amphetamines, ephedrine, epinephrine, norepinephrine, phenylephrine, pseudoephedrine: severe vasoconstriction and bradycardia Antihypertensives, nitrates: additive hypotension Clonidine: increased hypotension and bradycardia Digoxin: additive bradycardia Diltiazem, general anesthestics, phenytoin (I.V.), verapamil: additive myocardial depression Insulins, oral hypoglycemics: altered glycemic control Nonsteroidal anti-inflammatory drugs: decreased antihypertensive action Thyroid hormones: decreased nadolol efficacy Drug-behaviors. Acute alcohol ingestion: additive hypotension Cocaine use: severe vasoconstriction, bradycardia Patient monitoring• Monitor vital signs and peripheral circulation. Notify prescriber of heart rate below 55 beats/minute. Patient teaching• Advise patient to take drug with meals and a bedtime snack to minimize GI upset. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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