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nabumetone |
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nabumetone /na·bu·me·tone/ (nah-bu´mĕ-tōn) a nonsteroidal antiinflammatory drug used in the treatment of osteoarthritis and rheumatoid arthritis. nabumetone (n n brand name: Relafen; drug class: nonsteroidal antiinflammatory; action: inhibits prostaglandin synthesis by interfering with cyclooxygenase needed for biosynthesis; possesses analgesic, antiinflammatory, and antipyretic properties; uses: osteoarthritis, rheumatoid arthritis. nabumetone Gen-Nabumetone (CA), Relifex (UK) Pharmacologic class: Nonsteroidal anti-inflammatory drug (NSAID) Therapeutic class: Antiarthritic Pregnancy risk category C (first and second trimesters), D (third trimester) FDA Boxed Warning• Drug may increase risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. Risk may increase with duration of use. Patients with cardiovascular disease or risk factors for it may be at greater risk. ActionUnknown. Thought to stimulate anti-inflammatory response and block pain impulses by inhibiting cyclooxygenase, an enzyme needed for prostaglandin synthesis. AvailabilityTablets: 500 mg, 750 mg ⊘Indications and dosages ➣ Rheumatoid arthritis; osteoarthritis Adults: 1,000 mg/day P.O. as a single dose or in two divided doses; may increase up to 2,000 mg/day Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Give with food or milk to increase absorption.
Adverse reactionsCNS: dizziness, drowsiness, fatigue, headache, insomnia, malaise, nervousness CV: vasculitis EENT: abnormal vision, tinnitus GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, stomatitis, dry mouth, GI bleeding Skin: pruritus, rash, angioedema Other: edema, fluid retention, allergic reactions including anaphylaxis InteractionsDrug-drug. Acetaminophen: increased risk of adverse renal reactions (with chronic nabumetone use) Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid: increased risk of bleeding Antihypertensives, diuretics: decreased nabumetone efficacy Antineoplastics: increased risk of adverse hematologic reactions Aspirin, corticosteroids, other NSAIDs, potassium supplements: additive adverse GI effects Cyclosporine: increased risk of renal toxicity Insulins, oral hypoglycemics: increased hypoglycemic effect Methotrexate: increased risk of methotrexate toxicity Patient monitoring☞ Watch closely for signs and symptoms of angioedema, anaphylaxis, or other hypersensitivity reactions (including hives, swelling, shortness of breath, and abdominal pain). Patient teaching• Tell patient he may crush tablet if he can't swallow it whole. Patient discussion about nabumetone. Q. can u take nabumetone and dicfofenac at the same time A. Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and is used to treat pain or inflammation caused by arthritis. Nabumetone works by reducing the effects of hormones that cause pain and inflammation. Diclofenac is also a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in conditions such as arthritis or acute injury. It can also be used to reduce menstrual pain, dysmenorrhea. Since they both treat the same thing, there is no reason to take both. If you want to take both since they don't work then you probably need something stronger and should go see your Doctor about it. It's not recommended to mix medications. Read more or ask a question about nabumetoneHow to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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