nabumetone

nabumetone /na·bu·me·tone/ (nah-bu´mĕ-tōn) a nonsteroidal antiinflammatory drug used in the treatment of osteoarthritis and rheumatoid arthritis.

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nabumetone (nbū´mtōn´),

n brand name: Relafen;
drug class: nonsteroidal antiinflammatory;
action: inhibits prostaglandin synthesis by interfering with cyclooxygenase needed for biosynthesis; possesses analgesic, antiinflammatory, and antipyretic properties;
uses: osteoarthritis, rheumatoid arthritis.

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nabumetone

Gen-Nabumetone (CA), Relifex (UK)

Pharmacologic class: Nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Antiarthritic

Pregnancy risk category C (first and second trimesters), D (third trimester)

FDA Boxed Warning

• Drug may increase risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. Risk may increase with duration of use. Patients with cardiovascular disease or risk factors for it may be at greater risk.
• Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation. These events can occur at any time during use and without warning. Elderly patients are at greater risk.
• Drug is contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery.

Action

Unknown. Thought to stimulate anti-inflammatory response and block pain impulses by inhibiting cyclooxygenase, an enzyme needed for prostaglandin synthesis.

Availability

Tablets: 500 mg, 750 mg

⊘Indications and dosages

➣ Rheumatoid arthritis; osteoarthritis

Adults: 1,000 mg/day P.O. as a single dose or in two divided doses; may increase up to 2,000 mg/day

Contraindications

• Hypersensitivity to drug
• Active GI bleeding or ulcer disease
• History of aspirin- or NSAID-induced asthma, urticaria, or other allergic-type reaction
• Concurrent use of other NSAIDs
• Pregnancy (third trimester)

Precautions

Use cautiously in:
• severe cardiovascular, renal, or hepatic disease
• history of ulcer disease
• pregnant (first or second trimester) or breastfeeding patients
• children (safety and efficacy not established).

Administration

• Give with food or milk to increase absorption.
• In chronic therapy, use lowest effective dosage.

Route	Onset	Peak	Duration
P.O.	1-2 hr	5 hr	12-24 hr

Adverse reactions

CNS: dizziness, drowsiness, fatigue, headache, insomnia, malaise, nervousness

CV: vasculitis

EENT: abnormal vision, tinnitus

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, stomatitis, dry mouth, GI bleeding

Skin: pruritus, rash, angioedema

Other: edema, fluid retention, allergic reactions including anaphylaxis

Interactions

Drug-drug. Acetaminophen: increased risk of adverse renal reactions (with chronic nabumetone use)

Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid: increased risk of bleeding

Antihypertensives, diuretics: decreased nabumetone efficacy

Antineoplastics: increased risk of adverse hematologic reactions

Aspirin, corticosteroids, other NSAIDs, potassium supplements: additive adverse GI effects

Cyclosporine: increased risk of renal toxicity

Insulins, oral hypoglycemics: increased hypoglycemic effect

Methotrexate: increased risk of methotrexate toxicity

Patient monitoring

☞ Watch closely for signs and symptoms of angioedema, anaphylaxis, or other hypersensitivity reactions (including hives, swelling, shortness of breath, and abdominal pain).
• Monitor GI status. Report nutritional deficiencies.
• Assess vital signs.
• Monitor fluid intake and output.

Patient teaching

• Tell patient he may crush tablet if he can't swallow it whole.
• To minimize GI upset, advise patient to take drug with food; eat small, frequent servings of healthy food; and drink plenty of fluids.
• Advise patient to continue taking drug for entire duration prescribed.
☞ Teach patient to recognize and immediately report signs and symptoms of hypersensitivity reaction and angioedema (hives, swelling, shortness of breath, abdominal pain).
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, vision, strength, and alertness.
• Advise patient not to drink alcohol. Tell him to avoid aspirin, ibuprofen, and over-the-counter preparations (unless prescribed).
• Caution female patient not to take drug, especially during third trimester.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

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Patient discussion about nabumetone.

Q. can u take nabumetone and dicfofenac at the same time

A. Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and is used to treat pain or inflammation caused by arthritis. Nabumetone works by reducing the effects of hormones that cause pain and inflammation. Diclofenac is also a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in conditions such as arthritis or acute injury. It can also be used to reduce menstrual pain, dysmenorrhea. Since they both treat the same thing, there is no reason to take both. If you want to take both since they don't work then you probably need something stronger and should go see your Doctor about it. It's not recommended to mix medications.