The importance of correctly diagnosing MIFS is that it can be mistaken for either an inflammatory process or another malignant tumor such as Hodgkin lymphoma or a more aggressive sarcoma such as myxofibrosarcoma
Soft-tissue sarcomas are tumors arising from extraskeletal connective tissues and from Schwann cells and include fibrosarcoma, liposarcoma, hemangiopericytoma, rhabdomyosarcoma, lymphangiosarcoma, malignant fibrous histiocytoma, leiomyosarcoma, myxosarcoma, myxofibrosarcoma
, mesenchymoma, spindle cell tumors, and malignant peripheral nerve sheath tumors (neurofibrosarcoma, Schwannoma).
Based on these findings, the patient was differentially diagnosed with a primary malignant soft tissue tumor, such as a myxoid liposarcoma or myxofibrosarcoma
, or with a metastatic lesion of the adenocarcinoma of the prostate.
Examples of patients with aggressive cancers, such as pancreatic cancer, grade IV glioblastoma, stage 3 serous carcinoma of the uterus, stage 4 myxofibrosarcoma
, stage 4 invasive ductal carcinoma, chronic myelogenous leukemia, stage 4 colon cancer, and many others once diagnosed and treated for MSCIS, have resolution or stabilization of their cancers as evidenced at my clinic.
the stroma forms a diffuse myxoid granular film in the background and nuclear atypia and pleomorphism are often marked.
For example, MDM2 or CDK4 can show positivity in intimal sarcoma, pleomorphic rhabdomyosarcoma, a subset of malignant peripheral nerve sheath tumor, and myxofibrosarcoma
typically arises in the superficial soft tissue of the extremities; it is characterized by the presence of myxoid nodules displaying an arborizing, thick-walled vasculature.
4) Morphology of DDLS typically ranges from low to high grade components, commonly resembling myxofibrosarcoma
, malignant fibrous histiocytoma or sarcoma not otherwise specified.
FISH) but negative for MDM2 by IHC, whereas pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, and myxofibrosarcoma
may be positive for MDM2 by IHC but negative for MpM2 by FISH.
FIBROUS TUMORS: The malignant fibrous tumors included 3 cases of adult fibrosarcoma, 2 cases of fibromyxoid sarcoma and one case of Myxofibrosarcoma
and all were seen occurring over lower extremity in comparison with kransdorf study.
Occasional staining for TLE1 has also been described in clear cell sarcoma, high-grade chondrosarcoma, Ewing sarcoma, rhabdomyosarcoma, GIST, myxofibrosarcoma
, and leiomyosarcoma.
The differential diagnosis of aggressive angiomyxoma includes fibroepithelial stromal polyp, angiomyofibroblastoma, myxomas, superficial angiomyxoma, myxoid neurofibroma, myxoid liposarcoma, and myxofibrosarcoma