Examples of patients with aggressive cancers, such as pancreatic cancer, grade IV glioblastoma, stage 3 serous carcinoma of the uterus, stage 4 myxofibrosarcoma
, stage 4 invasive ductal carcinoma, chronic myelogenous leukemia, stage 4 colon cancer, and many others once diagnosed and treated for MSCIS, have resolution or stabilization of their cancers as evidenced at my clinic.
The differential diagnosis in this morphologic category include entities such as low-grade fibromyxoid sarcoma, myxoma, myxofibrosarcoma
, and myxoid liposarcoma (Table 2; Figure 2, e and f), which all have myxoid stroma, lack of a characteristic immunohistochemical profile, and (with the exception of examples of myxofibrosarcoma
) minimal/mild to no cytologic atypia.
IMT is distinguished from myxofibrosarcoma
and low-grade fibromyxosarcoma by the presence of diffuse inflammation and absence of typical delicate "curvilinear" vessels characteristic of these sarcomas.
Neoplasms that exhibit a glistening or mucoid tumor surface texture are frequently metastatic, mucin-secreting adenocarcinomas arising from the gastrointestinal tract or myxoid sarcomas, particularly myxoid liposarcoma, myxofibrosarcoma
, and myxoid malignant fibrous histiocytomas arising from the extremities, retroperitoneum, and other locations.
Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma
in the extremities and trunk: a comparison of clinicopathological and immunohistochemical features.
For those occurring in the superficial locations, the differential diagnosis mainly includes dermatofibrosarcoma protuberans (DFSP), soft tissue meningioma, and myxofibrosarcoma