myotoxin


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myotoxin

(mī′ō-tŏk-sĭn) [+ Gr. toxikon, poison]
A poison that destroys muscle cells. Myotoxins are found in a variety of venoms, esp. those delivered by the bite of certain poisonous snakes, such as adders and cobras.

myotoxin

toxins affecting muscle fibers only.
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3,4,7) Although federal and state health laboratories have not identified the heat-stable myotoxin in Haff disease, mice fed samples of toxic buffalo fish developed histopathological evidence of rhabdomyolysis with renal tubular myoglobin and myoglobinuria.
It was found that myotoxin probably causes renal damage due to myoglobin cast nephropathy.
Various other mechanisms have been suggested--directly acting cardiotoxin (5), myotoxin causing cardiac muscle damage, (6) coronary vasospasm, (7) electrolyte disturbance, (8) severe hypotension (9) and disturbance of autonomic innervation of the heart.
Wedelolactone also antagonized the myotoxic activity in mice of venoms from Crotalus viridis viridis and Agkistrodon contortrix laticinctus and two phospholipase A2 myotoxins, CVV myotoxin and ACL myotoxin, isolated from them [126].
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).
Natural phospholipase A(2) myotoxin inhibitor proteins from snakes, mammals and plants.
The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: an intravital and electron miocroscopic study.
Leatherhead Food RA are co-ordinating the European Myotoxin Awareness Network (EMAN), a European Commission funded project set up to combat lack of knowledge about this important safety issue.