myoglobinuria

my·o·glo·bi·nu·ri·a (m-glb-nr-)

n.

Excretion of myoglobin in the urine.

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Myoglobinuria

Reddish urine caused by excretion of myoglobin, a breakdown product of muscle.

Mentioned in: Alcohol-Related Neurologic Disease

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myoglobinuria

[-glō′binoo͡r′ē·ə]

Etymology: Gk, mys + L, globus + Gk, ouron, urine

the presence of myoglobin, an oxygen-storing pigment of muscle tissue, in the urine. The condition usually occurs after massive muscle injury, physical trauma, or electrical injury.

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myoglobinuria

the presence of myoglobin in the urine. It is evidence of severe muscle degeneration, though all such degenerations do not necessarily lead to myoglobinuria; it depends on the content of the pigment in the muscle and the renal threshold for it. The urine is red to dark red-brown, but in severe cases may be almost black.

Myoglobinuria in a horse with exertional myopathy. By permission from Knottenbelt DC, Pascoe RR, Diseases and Disorders of the Horse, Saunders, 2003

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paralytic myoglobinuria

see paralytic myoglobinuria.

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myoglobinuria

Internal medicine The loss of myoglobin in urine

Myoglobinuria, etiology  

Connective Tissue Disease Polymyositis, dermatomyositis

Hereditary Carnitine palmityl transferase deficiency, glycogen storage disease type V–phosphorylase deficiency, McArdle's disease, myopathies associated with glycogen or lipid storage, paroxysmal familial myoglobinuria, malignant hyperthermia, periodic paralysis

Infection

 Bacteria–eg, Legionnaire's disease

 Parasites–eg, trichinosis, toxoplasmosis

 Viral–eg, EBV, influenza, herpes

Toxins Alcohol–alcoholic myopathy, carbon monoxide, phencyclidine–PCP, 'angel dust', ethylene glycol, insect venom, some diuretics, Haff disease–historic interest

Trauma Crush injury, excess/prolonged physical exertion–eg, marathon running, severe muscle injury, crush injury

Etcetera Hyperthermia, infarction due to vascular occlusion, seizures

The diagnosis is based on clinical suspicion–especially with bright red urine and ↑ CK