TRV120023 increased the sensitivity of cardiac myofilaments
to calcium, suggesting that TRV120023 and molecules like it, such as TRV027, can increase cardiac contractile force ("inotropy") through a mechanism distinct from classic inotropes, which are associated with cardiac arrhythmia and increased mortality.
No cytoplasmic myofilaments
, melanosomes, or neurosecretory granules are present.
Various degrees of pathological alterations of myocardial structures were observed in all patients: loss of myofilaments
, degenerative changes in myofibrils, disarray and loss of myofibrils with changes in the shape and size of muscle cells, ultrastructural changes of the mitochondria, changes in nuclei and Golgi apparatus, changes in sarcoplasmic reticulum (16).
2011) confirmed that the peculiar recruitment in NMES and the resulting overrated mechanical stress might induce damage to cytoskeleton, myofilaments
and connective tissue surrounding muscle fibers.
Nonspecific intermediate filaments were present but no cytokeratin filaments or myofilaments
Troponin I binds to actin in thin myofilaments
, and holds the troponin-tropomyosin complex in place (56).
This is because addition of NaCl leads to selective binding of chloride ions to the positively charged groups in the myofibrillar network, consequently affecting the capillary forces through increased electrostatic repulsion between the myofilaments
High intensity, unaccustomed, or eccentric exercise can induce muscle damage, characterized by the disruption of myofilaments
and cytoskeletal elements (1), (2) as well as an inflammatory response.
Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: involvement of muscle myofilaments
Higher WHC in hot meat samples could be due to higher pH values and larger space between the myofilaments
and less denaturation of the meat proteins (Louck et al.
Presence of well-oriented, thin myofilaments
(60 to 80 [Angstrom]) in a large portion of the cytoplasm, joined to the membrane by dense bodies;
Levosimendan augments myocardial contractility by sensitising contractile myofilaments
to calcium without increasing myosin adenosine triphosphatase activity or oxygen consumption.