Invasive Lobular Carcinoma and Its Mimics Lesions CK ER CD34 Desmin SMA CD68 Invasive lobular carcinoma + + - - - - Myofibroblastoma
- + + + +/- - Mammary leiomyoma - + - + + - Fat necrosis - - - - - + Pseudoangiomatous stromal - +/- + - -/+ - hyperplasia Buzzard stromal cells - - - - -/+ - Abbreviations: CK, cytokeratin; ER, estrogen receptor; SMA, smooth muscle actin;+, positive staining;-, negative staining.
PASH has to be differenciated from a low-grade angiosarcoma, benign myofibroblastoma
and mammary hamartoma.
of soft tissue: A tumour closely related to spindle cell lipoma.
Mammary type myofibroblastoma
shows (long) fascicles, short stubby nuclei, broad bands collagen, as well as CD34 +/-, desmin +, SMA -/+ and RB1 deletion.
The overall histopathological and immunostaining patterns were interpreted as a myofibroblastoma
with prominent adipocytic component.
Chen, "Review of myofibroblastoma
of breast and its most common mimickers," American Chinese Journal of Medicine and Science, vol.
12) Recurrent dermatofibroma, hypertrophic scars, keloid, skin manifestations of myofibroblastoma
, metaplastic carcinoma, and fibromatosis are the most potential clinical differential diagnoses for DFSP tumors.
However invasive ductal carcinoma and myofibroblastoma
are some tumors known to arise from mammary hamartomas.
Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma
This lesion is also known as a plasma cell granuloma, myofibroblastoma
, inflammatory myofibroblastic tumor, and xanthomatous pseudotumor, and it occurs as the result of an inflammatory myofibroblastic proliferation and a pseudosarcomatous fibroinflammatory process.
This condition is indicated by the fact that IMT is known with several terms, such as inflammatory pseudotumour, plasma cell granuloma, inflammatory myofibroblastoma
and inflammatory myofibroblastic proliferation (3).
For the 75 cases considered nonamplified, diagnoses were lipoma (n = 46); intramuscular lipoma (n = 11); pleomorphic lipoma (n = 1); myofibroblastoma
(n = 1); sclerosing mesenteritis (n = 2); lipoma with fat necrosis (n = 4); pleomorphic sarcoma, not otherwise specified (n = 2); low-grade spindle cell neoplasm not further classifiable (n = 1); and benign mesenchymal myxoid neoplasm not further classifiable (n = 1).