Louise Hecker , the University of Arizona, "Impaired Myofibroblast
Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging"
5) The cell of origin for these lesions is believed to be the fibroblast or myofibroblast
Furthermore, the secretion of IL-1[beta] could be considered as an early event in cardiovascular and respiratory illness due to its capacity to induce apoptosis, inhibit myofibroblast
differentiation, and repress cell proliferation in rat lung fibroblasts (Zhang and Phan 1999).
expresses more alpha smooth muscle actin and has a phenotype with increased contractile force capacity.
Scientists said that the molecule - called alpha v integrin - is a critical switch involved in turning on the myofibroblast
cells to make scar tissue.
Immunohistochemical staining of NOS isoforms, PAI-1, [alpha]-SMA, IL-4, IL-13, and bFGF-positive cells in alveolar septa, as well as endothelial, myofibroblast
, and smooth muscle cells in terminal bronchiolar arteries, were quantified by stereology at 400 x magnification with an eyepiece systematic point-sampling grid with 100 points and 50 lines used to count the fraction of lines overlying the positively stained structures (27).
distribution in Dupuytren's cords: Correlation with digital contracture.
2) This occurs over a period of minutes or hours and so expansion or relaxation of myofibroblast
activity will certainly occur during the length of a Bowen treatment (normally around 45 minutes) as the person relaxes.
Surgical injury to the basement membrane and stroma results in abnormal collagen deposition, altered extracellular matrix and myofibroblast
formation contributing to fibrosis, reduced transparency, regression and decreased vision.
A range of molecules involved in epithelial damage and repair, inflammation, myofibroblast
accumulation and matrix deposition, angiogenesis, coagulation, and oxidative stress have been investigated for their potential in fulfilling this role, as biomarkers in tissue, bronchoalveolar lavage fluid, and serum, with a broadening of understanding of the events underlying the scarring of the lung (Table 1).
In addition to promoting myofibroblast
differentiation, transforming growth factor-[beta] [especially TGF-[beta]1] provides protection against apoptosis.
Inhibition of cardiac fibroblast proliferation and myofibroblast
differentiation by resveratrol.