MYOF

(redirected from myoferlin)

MYOF

A gene on chromosome 10q24 that encodes a membrane protein which is structurally similar to dysferlin and participates in calcium-mediated membrane fusion events, suggesting that it may have a role in membrane regeneration and repair.
References in periodicals archive ?
The research suggests that reducing production of the protein called myoferlin affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and altering mechanical properties of cancer cells--including their shape and ability to invade --so they are more likely to remain nested together rather than breaking away to travel to other tissues.
Explains coauthor Samir Ghadiali: "We believe the cells lacking myoferlin are made softer in the tumor so they can't physically detach away.
The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells - including their shape and ability to invade - so they are more likely to remain nested together rather than breaking away to travel to other tissues.