myocardial depressant factor

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Related to myocardial depressant factor: myocardial infarction

my·o·car·di·al de·pres·sant fac·tor (MDF),

a toxic factor in shock that impairs cardiac contractility; probably a peptide released with underperfusion of the splanchnic area at the release of proteolytic enzymes from the pancreas.

myocardial depressant factor

Uncertain; a substance allegedly present in the circulation that was once thought to be responsible for a suboptimal cardiac response to burns, shock and other stressing conditions (e.g.,accumulations of lactic acid and other stressants).

my·o·car·di·al de·pres·sant fac·tor

(MDF) (mī'ō-kahr'dē-ăl dĕ-pres'ănt fak'tŏr)
A toxic factor in shock that impairs cardiac contractility.


pertaining to the muscular tissue of the heart (the myocardium).

myocardial asthenia
myocardial weakness and decrease in the power of the heart's contraction, leading to reduction in cardiac reserve and ultimately to congestive heart failure.
myocardial cells
1. being surrounded by an intact sarcolemma prevents the cells forming a true syncytium; but do form a functional syncytium because of presence of gap junctions with low electrical resistance which allow the passage of ions and small molecules.
2. myocardial cells are specialized smooth muscle cells with acquired features and properties similar to those of skeletal muscles.
myocardial contractility
myocardium has an intrinsic periodic contractility which enables the denervated heart to continue beating; in the intact animal neurogenic control of contractility is paramount, inhibited by parasympathetic effects, stimulated by sympathetic effects.
myocardial damage
any disease causing loss of muscular or nervous function of the heart. Includes myocarditis, ischemia, degeneration.
myocardial depressant factor
substances liberated from the pancreas, intestine and liver during any type of circulatory shock. They reduce cardiac and reticuloendothelial activity and cause vasoconstriction. Called also MDF.
myocardial dystrophy
degenerative change in heart muscle, e.g. that occurring as a result of nutritional deficiency of selenium or vitamin E. Death usually occurs suddenly, with blood-stained froth pouring from the nostrils.
myocardial fiber
see myocardial cells (above).
myocardial heart failure
heart failure due to myocardial inefficiency.
myocardial hypertrophy
increase in size of myocardial muscle due to increase in size of individual myocardial cells, usually in response to an added afterload.
myocardial infarction (MI)
necrosis of the cells of an area of the heart muscle (myocardium) occurring as a result of oxygen deprivation, which in turn is caused by obstruction to the blood supply; commonly referred to in humans as a 'heart attack'. This is not a common disease in animals, but does occur, e.g. in horses, especially in the right atrium. It is a cause of myocardial weakness. See myocardial asthenia (above).
myocardial inflammation
myocardial injury
see myocardial damage (above).
ischemic myocardial necrosis
localized or widespread necrosis due to interruption of the blood supply via the coronary arteries.
myocardial lipofuscinosis
occurs in aged or cachectic cattle, also in healthy cattle; most common in Ayrshires; no apparent significance in terms of health; called also brown atrophy.
myocardial necrosis
focal or massive and subsequent scarring caused by infection, e.g. Histophilus somni, the encephalomyocarditis virus, nutritional deficiency, e.g. vitamin E-selenium, poisoning by plants, e.g. Acacia georgina, farm chemicals, e.g. monensin, and ischemic necrosis due to general or local inadequacy of blood supply to the myocardium.
myocardial tension
affects myocardial contractility but the importance of the effect in the living animal is obscure.
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