27,31,32) However, it is also contraindicated in patients with previous episodes of myelo-suppression (bone marrow suppression), those on myelotoxic
(bone marrow suppressive) drugs (typically used in chemotherapy), or patients with a history of allergic reaction to chloramphenicol.
BACKGROUND: Although benzene is known to be myelotoxic
and to cause myeloid leukemia in humans, the mechanism has not been elucidated.
Granulocyte colony stimulating factor (G-CSF) prophylaxis and febrile neutropenia (FN) incidence in patients with solid tumours receiving myelotoxic
chemotherapy who are assessed as high risk for FN: IMPACT SOLID study
This can be explained by the fact that myelotoxic
effect of zidovudine can persist as long as 12 wk (10).
On the other hand, the fact that the patient received radiotherapy along with hydroxyurea treatment may raise the question of chromosome breaks due to radiation and myelotoxic
If chemotherapy is to be used, the authors suggested that growth factor support should be given liberally with prophylactic acyclovir and co-trimoxazole on alternative days, steroids and dose-dense therapy should be avoided and the least myelotoxic
It is mildly myelotoxic
, but its main disadvantage is potential lung toxicity, which occurs in up to 40% of patients who then have a reported 1-10% mortality rate (1).
Background: Metamizole (dipyrone) is a myelotoxic
, nonsteroidal anti-inflammatory agent that has been banned from the US market since 1979.
This is consistent with the observation during Phase I clinical studies in solid tumours in adults that Aplidin(R) is rarely myelotoxic
(rarely toxic to normal white blood cells).
The liposomal anthracyclines (liposomal daunorubicin and pegylated liposomal doxorubicin) have mild myelotoxicity at the doses used in KS, and in general can be used even with myelotoxic
antiretroviral drugs such a zidovudine, when necessary.
Carboplatin is less nephrotoxic but slightly more myelotoxic
Certain other drugs have major organ toxicity at or near the myelotoxic