myeloproliferative neoplasms

myeloproliferative neoplasms

[mī′əlōprōlif′ərətiv′]
a family of chronic malignant bone marrow and blood diseases caused by mutations that generate clones of myelocytic or erythrocytic precursors and platelet precursors. Diseases include chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
References in periodicals archive ?
head of the Myeloproliferative Neoplasms Program at Memorial Sloan Kettering Cancer Center[sup.
Moreover, we have shown that damage to this regulatory network is essential for the manifestation of myeloproliferative neoplasms, diseases that were previously thought to be driven solely by mutated HSCs.
1,2) Myeloid sarcoma can occur de novo, concurrently or following the diagnosis of acute myeloid leukemias (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndromes (MDS).
30) In myeloproliferative neoplasms, the presence of the JAK2V617F mutation is of special interest.
Myeloproliferative neoplasms (MPNs) comprise a group of three distinct yet related myeloproloferative disorders: polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
The genetic background of myeloid malignancies, including acute myeloid leukemia (AML), [3] myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and myelodysplastic/myeloproliferative neoplasms (MDS/MPN), has been explored progressively in recent years, not only to better understand the underlying pathologic mechanisms of these vastly heterogeneous diseases but also to identify lesions that may serve as valuable diagnostic and prognostic markers, as well as possible drug targets.
Dr Ross Levine will present the results from a study on targeting the JAK-STAT pathway in myeloproliferative neoplasms.
Researchers have made some discoveries on the lighter side--like if you're likely to grow back hair or whether cilantro will taste like soap to you-and, Drabant adds, "then we have findings about Parkinson's, rare blood cancers, and myeloproliferative neoplasms.
development for the treatment of certain types of myeloproliferative neoplasms (MPNs), a group of blood cancers characterized by abnormal
Delhommeu F, Jeziorowska D, Marzac C, Casadevall N, Molecular aspects of myeloproliferative neoplasms, Int J Hematol.
According to the terms of the agreement, Ipsogen grants ARUP, a national clinical and anatomic pathology reference laboratory and a worldwide leader in innovative laboratory research and development, non-exclusive rights, for the US territory, to offer a complete range of assays for the molecular classification and the screening of Myeloproliferative Neoplasms (MPN), a group of leukaemia's caused by JAK2 gene variations that affects more than 100,000 people in the US.