myeloproliferative disorders


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myeloproliferative

 [mi″ĕ-lo-pro-lif´er-ah″tiv]
pertaining to or characterized by abnormal proliferation of bone marrow constituents.
myeloproliferative disorders a group of usually neoplastic diseases, which may be related histogenetically by a common multipotential stem cell; it includes among others acute myelogenous leukemia, chronic granulocytic leukemia, acute and chronic myelomonocytic leukemias, and polycythemia vera. An interrelationship with the lymphoproliferative disorders is thought to exist.

myeloproliferative disorders

[mī′əlōprōlif′ərətiv′]
a group of conditions characterized by proliferation of myeloid tissue, such as agnogenic myelofibrosis and myeloid metaplasia, polycythemia vera, or chronic myelogenous leukemia.

myeloproliferative disorders

A group of diseases featuring excessive production of blood cells by bone marrow precursors. The group includes POLYCYTHAEMIA VERA, chronic myelogenous LEUKAEMIA, platelet over-production (essential THROMBOCYTHAEMIA) and idiopathic MYELOFIBROSIS. A common feature is clonal haematopoiesis probably involving the haematopoietic stem cell. A high proportion of patients with these disorders have a mutation of the Janus kinase 2 (JAK2) gene on the short arm of chromosome 9.
References in periodicals archive ?
Prevalence ofJAK2 V619F mutation in Indian patients with chronic myeloproliferative disorders.
Portal vein thrombosis associated with a myeloproliferative disorder, prothrombin G20210A mutation, antiphospholipid syndrome, with repermeation during anticoagulant therapy.
MPL mutat on prof le n JAK2 mutat onnegative patients with myeloproliferative disorders.
This analysis supports the importance of individual variation on the thrombotic manifestations of the myeloproliferative disorder," he wrote.
JAK2 mutation has been shown to be associated with a wide spectrum of chronic myeloproliferative disorders (5-9).
This report provides information on the therapeutic development for Myeloproliferative Disorders, complete with latest updates, and special features on late-stage and discontinued projects.
Some topics addressed include cancer stem cells, viral pathogenesis, organoid as models for neoplastic transformation, disorders of vascular permeability, and pathogenesis of myeloproliferative disorders.
INTRODUCTION: It is one among the 4 Myeloproliferative disorders others are Polycythemia vera, Chronic Myeloid leukemia, Primary myelofibrosis.
The test searches for alterations in 95 genes that are frequently associated with leukemias and myeloproliferative disorders, detecting key mutations that determine prognosis and the specific drugs the cancer is most likely to respond to.
Further testing revealed a positive result for JAK2V617F mutations, which was strongly suggestive of ET as one of the three myeloproliferative disorders.
14-17) Patients with chronic myeloproliferative disorders (MPD) showed granulocyte activation parameters, and those with the JAK2 V617F mutation had significantly higher neutrophil counts, total white blood cell counts, and LAP levels.