Myeloperoxidase deficiency | definition of myeloperoxidase deficiency by Medical dictionary
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an autosomal-recessive inherited disorder in which there is a lack of myeloperoxidase in the primary granules of neutrophils, causing delayed intracellular killing of fungi and bacteria by neutrophils.
myeloperoxidase deficiency A common (1:500–2000) autosomal recessive condition (OMIM:254600) characterised by neutrophil dysfunction, resulting in a prolonged respiratory burst due to defective post-translational processing of an abnormal precursor protein.
Usually asymptomatic–Candida infection may occur in patients with concomitant diabetes.
Defects of MPO on chromosome 17p22 cause myeloperoxidase deficiency.
myeloperoxidase deficiency Molecular medicine A common–1:500-2000 AR condition characterized by neutrophil dysfunction, resulting in a prolonged respiratory burst due to defective post-translational processing of an abnormal precursor protein Clinical Usually asymptomatic–Candida infection may occur in Pts with concomitant DM Treatment Unnecessary
References in periodicals archive
In chronic granulomatous disease and myeloperoxidase deficiency
, patients have bacterial and candidal abscesses, but usually have normal IgE levels.
Bruchelt, Hagocytic-Activity and Oxidative Burst of Granulocytes in Persons with Myeloperoxidase Deficiency
Clinical manifestation of myeloperoxidase deficiency.
Genetic characterization of myeloperoxidase deficiency in Italy.
Hereditary myeloperoxidase deficiency
due to a missense mutation of arginine 569 to tryptophan.