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a hemoprotein having peroxidase activity, occurring in the primary granules of promyelocytes, myelocytes, and neutrophils, and that exhibits bactericidal, fungicidal, and viricidal properties.


(mī'ĕ-lō-per-oks'i-dās), [MIM*606989]
A peroxidase occurring in phagocytic cells that can oxidize halogen ions (for example, I-) with hydrogen peroxide to the free halogen, also producing two water molecules; an autosomal recessive deficiency of myeloperoxidase leads to impaired bacterial killing; formerly called verdoperoxidase because it is green. Compare: verdoperoxidase.


/my·elo·per·ox·i·dase/ (mi″ĕ-lo-per-ok´sĭ-das) a green hemoprotein in neutrophils and monocytes that catalyzes the reaction of hydrogen peroxide and halide ions to form cytotoxic acids and other intermediates; these play a role in the oxygen-dependent killing of tumor cells and microorganisms. Abbreviated MPO.

myeloperoxidase (MPO)

a peroxidase enzyme occurring in phagocytic cells that can oxidize halide ions, producing a bactericidal effect.


A gene on chromosome 17q23.1 that encodes myeloperoxidase during myeloid differentiation. MPO is the major component of neutrophil azurophilic granules and produces hypohalous acids (e.g., hypochlorous acid) and other toxic intermediates central to the microbicidal activity of netrophils.


a hemoprotein having peroxidase activity, occurring in the primary granules of promyelocytes, myelocytes and neutrophils, and which exhibits bactericidal, fungicidal and virucidal properties.
References in periodicals archive ?
SEM: Standard deviation, PGE: Punica granatum peel extract, OMZ: Omeprazole, SCF: Sucralfate, CMC: Carboxymethyl cellulose, URS: Unrestraint stress, UI: Ulcer index, CRS: Cold-restraint stress, MPO: Myeloperoxidase, GU: Gastric ulcer Table 2: Effects of PGE, OMZ, SCF, and PTX on UI and gastric mucosal protein, VEGF, TNF-[alpha], and IL-1[beta] in rat EtOH-induced GU Parameters UI Protein (mg/kg, odX7 days) (mg/g tissue) CMC 0.
Keywords: AML presentation, AML epidemiology, AML in Pakistan, Myeloperoxidase, AML-M2.
Thyroid core needle biopsy illustrates neoplastic cells staining positive for myeloperoxidase (A) and CD34 (B) (original magnification x40).
Expression of myeloperoxidase mRNA by leukemic cells from childhood acute lymphoblastic leukemia.
After this step, pneumonectomy was performed for the left lung, and the extracted tissue freezed in liquid nitrogen for malondialdehyde (MDA) and myeloperoxidase (MPO) measurements.
Neutrophil infiltration indicated by immunohistochemistry and myeloperoxidase activity
However, more than 10% cells took myeloperoxidase stain.
Although many previous reports have suggested that myeloperoxidase can regulate the functional effects of immune cells involved in the inflammatory disease of tissue injury using vitro models [24-26], further evidence is required to validate the effect of mpx regulation on innate immune cells.
Recently, studies of sepsis have expanded their focus to include microparticles formed as a result of PMN-derived insoluble myeloperoxidase (iMPO) endothelial and platelet cell activation.
Myeloperoxidase activity: The myeloperoxidase activity present in serum was measured according to Quade and Roth (1997) with slight modification by Sahoo et al.
T-cell subset expression in splenocytes, and serum cytokine production by activated T-cells, myeloperoxidase activity, swelling of footpad in delayed hypersensitivity (DTH), serum immunoglobulins, ceruloplasmin and lysozyme levels.