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a hemoprotein having peroxidase activity, occurring in the primary granules of promyelocytes, myelocytes, and neutrophils, and that exhibits bactericidal, fungicidal, and viricidal properties.
A peroxidase occurring in phagocytic cells that can oxidize halogen ions (for example, I-) with hydrogen peroxide to the free halogen, also producing two water molecules; an autosomal recessive deficiency of myeloperoxidase leads to impaired bacterial killing; formerly called verdoperoxidase because it is green. Compare: verdoperoxidase.
myeloperoxidase/my·elo·per·ox·i·dase/ (mi″ĕ-lo-per-ok´sĭ-das) a green hemoprotein in neutrophils and monocytes that catalyzes the reaction of hydrogen peroxide and halide ions to form cytotoxic acids and other intermediates; these play a role in the oxygen-dependent killing of tumor cells and microorganisms. Abbreviated MPO.
a peroxidase enzyme occurring in phagocytic cells that can oxidize halide ions, producing a bactericidal effect.
MPOA gene on chromosome 17q23.1 that encodes myeloperoxidase during myeloid differentiation. MPO is the major component of neutrophil azurophilic granules and produces hypohalous acids (e.g., hypochlorous acid) and other toxic intermediates central to the microbicidal activity of netrophils.
a hemoprotein having peroxidase activity, occurring in the primary granules of promyelocytes, myelocytes and neutrophils, and which exhibits bactericidal, fungicidal and virucidal properties.