Myeloma

myeloma /my·elo·ma/ (mi?e-lo´mah) a tumor composed of cells of the type normally found in the bone marrow.

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giant cell myeloma  see under tumor (1).

multiple myeloma  a disseminated type of plasma cell dyscrasia characterized by multiple bone marrow tumor foci and secretion of an M component, manifested by skeletal destruction, pathologic fractures, bone pain, the presence of anomalous circulating immunoglobulins, Bence Jones proteinuria, and anemia.

plasma cell myeloma  multiple m.

sclerosing myeloma  myeloma associated with osteosclerosis, most often manifested by peripheral neuropathy.

solitary myeloma  a variant of multiple myeloma in which there is a single localized tumor focus.

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my·e·lo·ma (m-lm)

n. pl. my·e·lo·mas or my·e·lo·ma·ta (-m-t)

A tumor composed of cells derived from hemopoietic tissues of the bone marrow.

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Myeloma

A tumor that originates in bone marrow and usually spreads to more than one bone.

Mentioned in: Bone Marrow Aspiration and Biopsy

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myeloma (mī´lō´m),

n a neoplasm characterized by cells normally found in the bone marrow.

myeloma, multiple,

n a primary malignant neoplasm of bone marrow characterized by proliferation of cells resembling plasma cells. Circumscribed radiolucencies are seen within the bones, and Bence Jones protein is usually found in the urine.

Multiple myeloma.

myeloma, plasma cell,

n a malignant neoplasm characterized by plasma cells. Solitary lesions may appear as radiolucencies in the bone and are sometimes considered benign, although most authorities believe that even these lesions become multiple and terminate fatally.

myeloma, solitary plasma cell,

n an incompletely understood monostotic neoplasm of bone that is histologically identical with multiple myeloma. Laboratory findings, positive in multiple myeloma, are usually negative in solitary plasma cell myeloma. Although usually benign, solitary plasma cell myelomas may be malignant.

myelomeningocele

(mī´lōmning´gōsēl),
n a condition in which part of the spinal cord protrudes from between the bones of the vertebrae. The condition can result in paralysis.

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myeloma

1. a B lymphocyte tumor.

2. multiple myeloma.

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giant cell myeloma

giant cell tumor (1).

multiple myeloma

a malignant neoplasm of plasma cells, in which the plasma cells proliferate and invade the bone marrow, causing destruction of the bone and resulting in pathological fracture and bone pain. A secretory form of the disease is characterized by the presence of an immunoglobulin recognized as Bence Jones protein (monoclonal immunoglobulin), Bence Jones proteinuria, anemia, and lowered resistance to infection. It is the most common type of monoclonal gammopathy. A non-secretory form of the disease also occurs.

osteosclerotic myeloma

multiple myeloma associated with osteosclerosis (rather than bone destruction) and often with peripheral neuropathy.

plasma cell myeloma

see multiple myeloma (above).

myeloma protein

the immunoglobulin molecules produced by myeloma cells. See gammopathy.