Acute myelogenous leukaemia (AML) is a condition characterized by malignant transformation of blood cells belonging to myeloid series
that consists of granulocytes, monocytes, erythrocytes, and megakaryocytes.
Peripheral smear showed macrocytic RBCs, shift to left in the myeloid series with 02% myeloblasts, 03% promyelocytes, 25% myelocytes, 10% metamyelocytes, 46% bands/stabs/neutrophils, 06% eosinophils and 08% basophils [Figure 7].
Chronic myeloid leukemia is a pluripotential stem cell disorder characterised by anemia, markedly elevated leucocyte count with shift to left in the myeloid series, basophilia, often thrombocytosis and splenomegaly.
The myeloid series of cells showed 52% blasts, only 5% mature lymphocytes, and 1% plasma cells [Figure 3].
The myeloid series showed 94% CD13, 82% CD33, 88% CD117, 73% CD34, and 41% HLA-DR positive.
Bone marrow aspiration from the sternum showed a hypocellular marrow with complete absence of the erythroid series, a normal myeloid series
, and megakaryocytes.
No other important findings were noted, except for an evident increase in myeloid series and megakaryocytes (more evident in erythroid series) on bone marrow aspiration and biopsy.
No other important findings were noted except for an evident increase in myeloid series and megakaryocytes (more evident in erythroid series) on bone marrow aspiration and biopsy.
The myeloid series
was left-shifted with a relative predominance of promyelocytes and myelocytes (Figure 2).
63%) patients showed normal pattern of maturation in myeloid series, 5(23.
In myeloid series dysmyelopoeisis and reduction in myelopoeisis was noted in both the groups.
FNAC smears showed presence of myeloid series
of cells in varying stages of maturation composed of predominantly myelocytes, metamyelocytes, basophils and eosinophils.