myeloid metaplasia

metaplasia /meta·pla·sia/ (met″ah-pla´zhah) the change in the type of adult cells in a tissue to a form abnormal for that tissue.metaplas´tic

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myeloid metaplasia  a syndrome characterized by myeloid tissue in extramedullary sites with nucleated erythrocytes and immature granulocytes in the circulating blood and extramedullary hematopoiesis in the liver and spleen, as well as anemia and splenomegaly. Both a primary form (agnogenic myeloid m.) and forms secondary to carcinoma, leukemia, leukoerythroblastosis, and tuberculosis are known.

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myeloid metaplasia

n.

A syndrome characterized by anemia, enlargement of the spleen, and the presence of nucleated red blood cells and immature granulocytes in the blood, and accompanied by extramedullary hematopoiesis in the spleen and liver.

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myeloid metaplasia,

a disorder in which bone marrow tissue develops in abnormal sites. Characteristics of the condition are anemia, splenomegaly, immature blood cells in the circulation, and hematopoiesis in the liver and spleen. Myeloid metaplasia may be secondary to carcinoma, leukemia, polycythemia vera, or tuberculosis. The primary form is called agnogenic myeloid metaplasia, aleukemic myelosis.

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metaplasia [met″ah-pla´zhah]

the change in the type of adult cells in a tissue to a form abnormal for that tissue. adj., adj metaplas´tic.

agnogenic myeloid metaplasia the primary or idiopathic form of myeloid metaplasia, which is often accompanied by myelofibrosis; it is considered one of the myeloproliferative disorders. Called also aleukemic or nonleukemic myelosis.

myeloid metaplasia the occurrence of myeloid tissue in extramedullary sites; specifically, a syndrome characterized by splenomegaly, anemia, nucleated erythrocytes and immature granulocytes in the circulating blood, and extramedullary hematopoiesis in the liver and spleen. The primary form is called agnogenic myeloid metaplasia. The secondary or symptomatic form may be associated with various diseases, including carcinomatosis, tuberculosis, leukemia, and polycythemia vera.

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myeloid

1. pertaining to, derived from or resembling bone marrow.

2. pertaining to the spinal cord.

3. having the appearance of myelocytes, but not derived from bone marrow.

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myeloid:erythroid (M:E) ratio

the ratio of myeloid to erythroid cells found in an examination of the bone marrow; provides an assessment of bone marrow activity.

myeloid leukemia

see myelocytic leukemia.

myeloid leukosis

see myeloblastosis (2).

myeloid metaplasia

hyperplasia of the bone marrow, with erythroid phthisis and compensatory splenomegaly and sometimes hepatomegaly. It is usually succeeded by bone marrow fibrosis and sclerosis. The initiating cause is usually not apparent.

myeloid tissue

red bone marrow.