myelodysplasia

myelodysplasia /my·elo·dys·pla·sia/ (-dis-pla´zhah)

1. a neural tube defect causing defective development of any part of the spinal cord.

2. dysplasia of myelocytes and other elements of the bone marrow.myelodysplas´tic

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my·e·lo·dys·pla·sia (m-l-ds-plzh)

n.

Abnormal development of the spinal cord.

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myelodysplasia

[mī′əlōdisplā′zhə]

Etymology: Gk, myelos + dys, bad, plassis, formation

1 a general designation for the defective development of any part of the spinal cord. The term is used primarily to describe abnormalities without gross superficial defects, especially of the lower segment, specifically spina bifida occulta.

2 dysplasia of the myelocytes and other elements in bone marrow.

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myelodysplasia [mi″ĕ-lo-dis-pla´zhah]

1. a neural tube defect consisting of defective development of part of the spinal cord. See also spina bifida.

2. dysplasia of myelocytes and other elements of the bone marrow, a chronic disease that in time may evolve into acute myelogenous leukemia. adj., adj myelodysplas´tic.

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myelodysplasia

1. defective development of the spinal cord.

2. disorders of myeloid cells of the bone marrow, either in number or degree of maturity.

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hemopoietic myelodysplasia

includes myeloid metaplasia and myelofibrosis, refractory anemia with excess blast cells, and myelomonocytic leukemia.

myelodysplasia syndrome

qualitative defect in stem cells characterized by dysplastic hematopoietic cells and the presence of abnormal blast cells in the blood. There is also anemia, leukopenia and sometimes thrombocytopenia. See also myeloproliferative disease.

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myelodysplasia

Hematology Abnormal BM precursor cells, which may lead to CML. See Myelodysplastic syndrome Neurology A generic term for various developmental defects of the spinal cord and nerve roots–eg, myelomeningocele, sacral agenesis, spinal dysraphism and caudal regression syndrome;¹⁄₃ of infants with myelodysplasia develop external urethral sphincter dysfunction, often in the first 3 yrs of life, ¹⁄₂of which are permanent.