Iomab-B is intended to provide safer myeloablation
of the bone marrow prior to a bone marrow transplant, thus providing a potentially curative treatment option for this patient population and for patients with other leukemias, lymphomas, myelomas and other blood disorders.
Changes to the study protocol for HGB-206 include increasing the percentage of transduced cells through manufacturing improvements, improving myeloablation
(and subsequent engraftment) by increasing the target busulfan area under the curve, introducing a minimum period of regular blood transfusions prior to stem cell collection, improved cell processing and exploring an alternate hematopoietic stem cell procurement method.
Preclinical targeting of human acute myeloid leukemia and myeloablation
using chimeric antigen receptor-modified T cells.
At both 54 and 48 months, a comparison of global rank composite scores favored myeloablation
followed by CD34+-selected autologous hematopoietic stem cell transplantation (HSCT) over 12 monthly pulses of 750 mg/[m.
Transplant modalities included combinations of matched/mismatched and related/unrelated donors from umbilical cord blood, peripheral blood, and bone marrow, with or without myeloablation
and autologous peripheral blood stem cell rescue results in hematologic and clinical responses in patients with myeloid metaplasia with myelofibrosis.
Conditioning, also known as bone marrow preparation or myeloablation
, is treatment with high-dose chemo and/or radiation therapy.
The specifics of myeloablation
are beyond the scope of this review.
To validate this possibility, we chose allogeneic HSCT as a model system, because BM content varies widely from the short period of time between myeloablation
and full recovery.
However, thrombopoietins are ineffective in thrombocytopenias due to myeloablation
as a consequence of the inherent kinetics of thrombopoiesis (5).
Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation
The killing of bone marrow by chemotherapy and/ (ablation) or radiation.