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Cellular and humoral immune reaction against a variety of neural cell antigens, such as myelin basic protein, myelin oligodendrocyte glycoprotein, myelin associated glycoprotein, ganglioside, sulfatide, and many other self-antigens, may result in a neuroimmune disorder including interference with neurotransmission.
Treatable gait disorders and polyneuropathy associated with high titer serum IgM binding to antigens that copurify with myelin associated glycoprotein.