myc


Also found in: Dictionary, Acronyms, Wikipedia.

Myc

(mĭk)
n.
Any of several genes encoding DNA-binding proteins that can promote the development of various cancers when present at high concentrations.

myc

An oncogene on chromosome 8q24 of cellular (c-myc) or viral (v-myc) origin, which was first identified in the genome of a group of acutely transforming retroviruses capable of inducing avian neoplasia, possibly linked to RNA processing.

Physiological
c-myc is present in normal tissues; the protein product is required for progression through the cell cycle. Myc-null cell lines show profound growth defect, with lengthening of G1 and G2 phases of the cell cycle. There is a marked reduction in cyclin D1-CDK4 and D1-CDK6 complexes during entry to S phase, with lesser reductions in cyclin E2-CDK2 and cyclin A-CDK2. Myc induces expression of cyclins D1 and D2.

Pathological
Oncogenic expression of c-myc involves mutations on exon 2, which occur in more than 50% of Burkitt's lymphomas. The typical translocation in Burkitt’s lymphoma is t(8;14)(q24;q23), juxtaposing the c-myc and the immunoglobulin heavy-chain genes. Variant translocations are to 2p11 or 22q11, juxtaposing kappa or lambda light-chain genes respectively. FISH performed with dual probes can demonstrate the IgH/c-myc translocation. Tricolour with a probe against the centromere of chromosome 8 will control c-myc amplification or loss of the derivative chromosome 8; dual colour break-apart probes will show splitting of the gene.
References in periodicals archive ?
Identifying the threshold was important because Myc functions in both healthy and cancerous cells as a transcription factor, a protein signal that binds DNA to turn genes on or off.
In this study, our idea was to switch MYC off, interfering with its ability to activate the cell-growth program," Bradner explained.
Tests revealed high concentrations of Myc in the tumors.
Bister added: "Because the gene has been conserved in evolution all the way from Hydra to humans, we are now able to analyze biological and biochemical functions of the myc gene in detail and draw conclusions for the human organism.
All religious parties in MYC will attend the meeting.
However, the current study has for the first time shown that the altered Myc gene, called an oncogene, can also act directly on the final stage of protein production.
The team made these findings in Eu-Myc laboratory models, which overexpress Myc in B cells and are widely used in laboratory studies of cancer.
Jude researchers report that TEL2 cooperates with MYC to increase the chance that a certain mutation will occur in precancerous B lymphocytes, permitting these cells to become cancerous.
He underscored that those religious parties that could not join the DPC owing to some political issues and reservations would now be able to join the revived alliance under the platform of MYC.
The Myc family of oncogenes (c-Myc, N-Myc, and L-Myc) help control tumor cell growth, differentiation and development.
Scientists already suspect the oncogenes myc and ras have a role in the disease.
Evan, a scientific advisor to ATI, has established a clear link between regulation of expression of the myc gene and apoptosis.