mutation detection

mutation detection

Any method used to detect a substance’s mutagenic activity, the gold standard for which is the Ames test, an in vitro assay designed to determine an agent’s ability to induce mutations in bacteria.
References in periodicals archive ?
Quotation are invited for Supply of EGFR Mutation detection kit-40-50 samples(IVD/CE certified)
The cobas EGFR Mutation Test v2 is designed for expanded EGFR mutation detection in non-small cell lung cancer patients
The success and ongoing value of "real world" studies like ASSESS and IGNITE underline AstraZeneca's position in pioneering the role of diagnostics in EGFR mutation detection.
COLD-PCR: A new platform for highly improved mutation detection in cancer and genetic testing.
Archer captures and amplifies only gene targets of interest and offers dramatic enhancements in scalability, mutation detection speed, complex mutation identification and reduced costs.
This technology is limited to specific mutation detection, albeit in a fairly high capacity, which requires a unique assay for each mutation in a complex multiplexed mixture.
454 Life Sciences, a Roche Company (SWX:RO)(SWX:ROG)(Pink Sheets: RHHBY), has announced promising new results from a multi-site collaborative research study which used the company's Genome Sequencer FLX System to perform HIV drug-resistant mutation detection.
To increase the CFTR mutation detection rate in black and coloured South African CF patients for molecular diagnosis, we tested patients with a clinical phenotype of CF, and at least one unidentified CFTR mutation, for exon CNVs in the CFTR gene: 24 coloured patients (of Khoisan, Malay, European and African admixture), most of whom originate from the Western Cape, and 18 black patients (sub-Saharan African origin) were tested.
Other new tests available include the ProGenotyper Filaggrin Mutation Detection Test, the latest in the company's menu of molecular assays to investigate skin diseases, and the T-Cell Rx assay, which adds to its line of tests for adverse drug reactions and assists physicians assessing patients who have experienced a delayed drug reaction.
Although real-time PCR or pyrosequencing is more rapid than high-throughput assays for mutation detection (4,5), the conventional PCR technique can be applied to detect drug-resistant mutation (6) in areas lacking real-time PCR or pyrosequencing capabilities.
The title of the article is: 'Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing.
Didenko (Baylor College of Medicine) presents 22 chapters detailing laboratory protocols for using fluorescent nucleic acid probes for hybridization detection, DNA breaks and cleavage monitoring, synthesis and amplification visualization, sequence analysis and mutation detection, and determination of distances and DNA folding.