mutasynthesis

mutasynthesis

the synthesis of new products by MUTANT ORGANISMS that have blocks in a specific biosynthetic PATHWAY so that they cannot make the end product. When provided with an unnatural SUBSTRATE (3), the pathway may be completed with the formation of a novel end product. Such an approach has been used to produce new ANTIBIOTICS.
References in periodicals archive ?
ambifaria and enacyloxin analogues, with a stable amide group in place of the labile ester group and other modifications to the DHCCA-derived moiety, will be produced via a mutasynthesis strategy.
Efforts to reprogram the biosynthesis of enterocins and wailupemycins include the mutasynthesis of analogues of enterocin with non-natural starter units in which the authors fed aryl acids to a strain of S maritimus that was incapable of producing benzoate-primed polyketides.
Mutasynthesis of enterocin and wailupemycin analogues.