Benchmark Data Set for in Silico Prediction of Ames Mutagenicity
cytochrome P450, lessens almost completely the mutagenicity
of the extracts of chlorinated waters.
Role of mutagenicity
in mineral fiber-induced carcinogenicity and other diseases.
46] Umbuzeiro GD, Roubicek DA, Sanchez PS and Sato MIZ (2001) The Salmonella mutagenicity
assay in a surface water quality monitoring program based on a 20-year survey.
The effect of flavonoids on ofloxacin-induced mutagenicity
in Euglena gracilis.
and recombinogenicity of daunomycin in Saccharomyces cerevisiae.
coli tester strains recommended by regulatory agencies and evaluates colony formation, cytotoxicity and compound precipitation using an agar format, factors that make this screen the most predictive mutagenicity
screen for the regulatory GLP Ames assay - a claim no other company can make.
Big Blue is identified in OECD Test Guideline 488, as well as recommended by various agencies and expert groups, including the European Chemicals Agency, as an accepted assay for evaluating mutagenicity
in somatic and male germ cell tissues.
Sarah Nexus combines our expertise in mutagenicity
with novel machine-learning algorithms to provide predictions that are supported by estimates of accuracy, clear explanations of how they are derived and direct access to the underlying supporting data.
KEY WORDS: Ames assay, carcinogenicity, 21st century toxicology, genetic toxicology, high-throughput assays, Salmonella assay, Salmonella mutagenicity
DBM has been reported to antagonize the mutagenicity
of several chemical carcinogens in vitro and has recently been shown to be even more effective than curcumin in suppressing the 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in rats.
Scientists use mutagenicity
-- the ability to cause genetic mutation -- as a rough gauge of potential carcinogenicity.