MLH1

(redirected from mutL)

MLH1

A human homologue of the Escherichia coli DNA mismatch repair gene on 3p21.3, which encodes an enzyme that scans newly replicated DNA for errors and repairs mismatched base pairs.

Molecular pathology
A germline mutation of MLH1 occurs in ± 1% of patients with hereditary nonpolyposis colon cancer; defects in MLH1 also cause mismatch repair cancer syndrome, Muir-Torre syndrome and susceptibility to endometrial cancer.
References in periodicals archive ?
05 BRAF, proto-oncogene B-Raf/v-Raf murine sarcoma viral oncogene homolog B; CI, confidence interval; CPG, clinical practice guideline; CRC, colorectal cancer; CT, chemotherapy; DS, direct sequencing; EGFR, epidermal growth factor receptor; HR, hazard ratio; KRAS, Kirsten rat sarcoma viral oncogene homolog; mAbs, monoclonal antibodies; mCRC, metastatic colorectal cancer; MLH1, mutL homolog 1; Mut-, mutation negative or wild type; Mut+, mutation positive; NR, not reported; ns, nonsignificant; ORR, objective response rate; OS, overall survival; PCR, polymerase chain reaction; PFS, progression-free survival; P/K3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; RR, response rate; RFS, recurrence-free survival; SR, systematic review; xMAP, multiplex assay.
Seven genes, including epidermal growth factor receptor (EGFR), G protein subunit alpha S (GNAS), HRas proto-oncogene (HRAS), mutL homolog 1 (MLH1), cadherin 1 (CDH1), neuroblastoma RAS viral oncogene homolog (NRAS), and NOTCH1, that only occurred m utations in the resistant group were associated with the resistance of targeted therapy.
1%) in any traits were phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2), and ADAM metallopeptidase domain 12 (ADAM12).
Posteriormente, el complejo MutL (MLH1-PMS2) en presencia de ATP, reconoce la secuencia de ADN hemimetilado generando un rompimiento de la cadena debido a su actividad de endonucleasa.
Muthuri aikarlire njungwa onaga haraihu guklra kihii kiri mutl iguru [gikuyu].
Refuting Al-Atheina's statement that PAHW has only 38,000 units at present, he said the Authority has 168,400 units distributed as follows; 52,000 in north Mutl, 22,000 in Mutl outskirts, 52,000 in Sabiya, 35,000 in Khairan and 7,400 in west Abdullah Al-Mubarak area.
For instance, there are three major MMR proteins constituted in vitro: MutS, MutL, and MutH.
AR) 1,394 Net Premiums Written--Life Individual Life #1 Northwestern Mutl Life Ins Co.
Standard DNA amplification and sequencing of 7 housekeeping genes (acsA, aroE, guaA, mutL, nuoD, ppsA, and trpE) were performed.
55) SCC, Squamous cell carcinoma; ADC, Adenocarcinoma; LOH, loss of heterozygosity; TSG, tumor suppressor gene; APC, adenomatous polyposis coli; MLH1, mutL homolog1.
The McMaster researchers uncovered how a specific protein, known as MutL, works within a cell to unleash the series of events that repair DNA when the replication machinery makes a mistake.