The lamina propria and muscularis mucosa of the inner mucous membranes were normal, and the vascular endothelia were regular.
But rats from the model group displayed tissue separation due to ulceration of the colon mucous membranes, massive granular cell infiltration of the submucosa and muscularis mucosa, and severe ulcerations to the depth of the submucosal vasculature.
Tissue slices from the UC model rats showed tissue separation due to ulceration of colon mucous membranes, and massive granular cell infiltration of the submucosa and muscularis mucosa.
Recent histopathologic studies have characterized the morphologic features of the mucosal EGJ and defined the following histologic features of the mucosal EGJ as the distal ends of (1) squamous mucosa or islands (Figure 4); (2) deep esophageal glands and ducts (Figure 5); (3) multilayered epithelium (Figure 6) and hybrid glands; and (4) double-layered muscularis mucosa.
25) Other landmarks for the esophagus include (1) a double layer of the muscularis mucosa, which can be identified in up to 87% of patients with Barrett esophagus (24) but is found to be nonspecific for the esophagus because it is also seen in hiatal hernias and postradiation/sclerotherapy or biopsy (20); and (2) a multilayered epithelium, which is noted to be the precursor of CLE and Barrett esophagus and present only in the distal esophagus as a result of reflux-induced esophageal injury.
Only few questionable nerve twigs were present in the muscularis mucosa and lamina propria (Figure 1c).
Immature GCs are usually present in clusters called neural units, which are more readily recognized underneath the muscularis mucosa.
1,3,5) Biopsy specimens from patients with HSCR show AChE-positive thick fibers in the muscularis mucosa extending to a variable length in the lamina propria (Figure 6, b), and biopsy samples from ganglionic bowel may show only few or absent cholinergic fibers.