muscular atrophy


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

mus·cu·lar at·ro·phy

wasting of muscular tissue. Compare: myopathic atrophy.
Synonym(s): myatrophy, myoatrophy

muscular atrophy

a condition of motor unit dysfunction, usually the result of a loss of efferent innervation.

muscular atrophy

(1) Disuse atrophy, see there.
(2) Spinal muscular atrophy, see there.

mus·cu·lar at·ro·phy

(mŭs'kyū-lăr at'rŏ-fē)
Wasting of muscular tissue.

muscular atrophy,

n decrease in size and number of muscle fibers as a result of aging, reduction in blood supply, malnutrition, or denervation. See also innervation.

mus·cu·lar at·ro·phy

(mŭs'kyū-lăr at'rŏ-fē)
Wasting of muscular tissue.

muscular

1. pertaining to a muscle.
2. having well developed muscles.

muscular asymmetry
due usually to neuronal or disuse atrophy on one side of the body.
muscular atrophy
wasting away of muscle or a muscle because of reduction in cross sectional area of muscle fibers; may be due to disease of the muscle or its nerve supply, or to disuse or nutritional inadequacy. See also hereditary spinal muscular atrophy (below).
muscular degeneration
varies in severity from degeneration of only the myofibrils or degeneration of the myofibrils plus sarcoplasm, leaving satellite cells and myonuclei and sarcolemmal laminae unaffected, or further levels of increasing severity.
muscular denervation
destruction or congenital absence of the motor nerve supply to the muscle; manifested by paralysis and atrophy and absence of spinal reflexes.
muscular denervation atrophy
progressive shrinkage of muscle fibers when the nerve supply to the muscle is severed.
Duchenne muscular dystrophy
an X-linked inherited disease in humans, which is believed to be due to a deficiency of a membrane-associated protein, dystrophin. An analogous disease has been identified in Irish terriers, Golden retrievers and mice.
muscular dystrophy
any degenerative muscular disorder due to faulty nutrition of the muscles. Causes muscle weakness, liberation of myoglobin into the circulation from skeletal muscle and subsequent wasting and possible contracture. In humans there are a group of genetically determined, painless, degenerative myopathies that are progressively crippling because muscles are gradually weakened and eventually atrophy. In food animals the principal disease in this group is enzootic muscular dystrophy caused by a nutritional deficiency of selenium and/or vitamin E. Sporadic cases of muscular dystrophy of unknown etiology occur rarely in dogs.
muscular fascicle
muscular fasciculation
muscular fatigue
during brief, intense exercise probably due in large part to the accumulation of lactate.
hereditary spinal muscular atrophy
progressive degeneration of the motor cells of the spinal cord. It is an inherited, slowly progressive flaccid tetraparesis from an early age, with muscular atrophy. Occurs as an autosomal recessive trait in Swedish lapland dogs, a dominant trait in Brittany spaniels. Also reported in German shepherd dogs, English pointers and Rottweilers. See also hereditary neuronal abiotrophy of Swedish Lapland dogs. In cattle, inherited as an autosomal recessive trait and reported in Brown Swiss, Holstein-Friesian and Red Danish calves with an onset at 3 to 8 weeks of age. There is hind limb ataxia progressing to recumbancy. Associated with lesions in the lower motor neurons of the cervical and lumbar spinal cord.
muscular hernia
hernia through an enclosing muscle sheath.
muscular hyperplasia
an increase in the size of a muscle mass due to an increase in the number of muscle cells. See also myofiber hyperplasia, ileal muscular hypertrophy.
muscular hypertrophy
an increase in the size of a muscle mass due to an increase in the length and thickness of each muscle cell without any increase in the number of cells.
muscular ischemia
short duration or temporary or partial cessation of blood supply causes loss of muscle power and possibly some muscle fiber necrosis; long duration or severe or complete cessation cause ischemic muscle necrosis and atrophy. See also compartment syndrome, downer cow syndrome.
muscular ischemic necrosis
see ischemic myonecrosis.
muscular mineralization
ectopic deposition of minerals in muscle. See mineralization.
myelopathic muscular atrophy
muscular atrophy due to a lesion of the spinal cord, as in spinal muscular atrophy.
nutritional muscular dystrophy
see muscular dystrophy (above).
muscular parasitic diseases
includes cysticercosis, hepatozoonosis, Neosprum caninum myositis, sarcocystosis, toxoplasmosis, trichenellosis.
muscular receptors
muscle spindles which respond to stretch.
muscular steatosis
excess fat deposits in muscle; a problem only at meat hygiene inspection.
muscular vascular occlusive syndrome
see ischemic myonecrosis.
muscular weakness
X-linked muscular dystrophy
see Duchenne muscular dystrophy (above).
References in periodicals archive ?
In the case of spinal muscular atrophy, protein abnormalities prevent the normal functioning of motor neurons, leading to their deterioration and muscle degeneration.
Coverage of the Spinal Muscular Atrophy (SMA) pipeline on the basis of route of administration and molecule type.
et al: Clinical observation of juvenile non-progressive muscular atrophy localized in hand and forearm.
This held true for both causes of muscular atrophy.
Current statistics show an 8-month average lifespan for a child born with spinal muscular atrophy Type 1 who is not put on a ventilator, according to Ms.
The Roopes learned of the program when Tyler saw a man with an assistance dog at a conference in Chicago for families of people with spinal muscular atrophy.
The absence of gravity modifies blood circulation, causes muscular atrophy and reduces bone density,' said Bedrest co-ordinator Anne Pavy-Le Thraon.
com/research/jl9dv2/spinal_muscular_at) has announced the addition of Global Markets Direct's new report "Spinal Muscular Atrophy (SMA) - Pipeline Review, H1 2012" to their offering.
Biogen (BIIB) and Ionis Pharmaceuticals (IONS) announced end of study results from CHERISH, the Phase 3 study evaluating SPINRAZA for the treatment of individuals with later-onset spinal muscular atrophy, were published in The New England Journal of Medicine.
Spinraza was approved for individuals with infantile-onset spinal muscular atrophy by the Pharmaceuticals and Medical Devices Agency in Japan in June 2017.
ClickPress, Thu Mar 26 2015] Global Markets Direct's, 'Spinal Muscular Atrophy (SMA) - Pipeline Review, H1 2015', provides an overview of the Spinal Muscular Atrophy (SMA)'s therapeutic pipeline.
M2 EQUITYBITES-March 9, 2015-Isis Pharmaceuticals earns USD9m for progressing ISIS-SMN Rx into Phase 3 study in infants with spinal muscular atrophy