muscarinic antagonist


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mus·ca·rin·ic an·tag·o·nist

drugs that bind with muscarinic cholinergic receptors but do not activate them, thus preventing access to acetylcholine; examples include atropine, scopolamine, propantheline, and pirenzepine.
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3] to compare RPL554 to placebo, when administered with a beta2 agonist (salbutamol), and with a muscarinic antagonist (ipratropium).
NASDAQ: PULM) will report data from a Phase 1B study evaluating PUR0200, an iSPERSE formulation of a long acting muscarinic antagonist (LAMA) bronchodilator, on September 29[sup.
As a muscarinic antagonist (blocker), trospium chloride could potentially inhibit xanomeline's binding to peripheral receptors, and therefore improve xanomeline's safety profile.
AstraZeneca owns the development and commercial rights in the US and Canada to TudorzaTM PressairTM (aclidinium bromide inhalation powder), a twice-daily long-acting muscarinic antagonist (LAMA) for chronic obstructive pulmonary disease (COPD), and to DalirespA (roflumilast), the only once-daily oral PDE4 inhibitor currently on the market for COPD, in the US.
Since, there was no notable reduction in the contractile response to [alpha]-hederin after pretreatment with atropine (non-selective muscarinic antagonist), any specific muscarinic antagonist was employed in further study of [alpha]-hederin mode of action.
The long-acting muscarinic antagonist (LAMA)/LABA programme is in Phase III development in COPD.
Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve.
69) A more selective muscarinic antagonist, which inhibits myopia but does not affect these other ocular functions, would provide a more attractive treatment for the inhibition of myopia development.
Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that interviewed payers in the EU5 (France, Germany, Italy, Spain and the United Kingdom) are confident that emerging long-acting beta2 agonist (LABA)/ long-acting muscarinic antagonist (LAMA) fixed-dose combinations (FDCs) will likely be admitted for reimbursement at the national level but these payers warn that the reimbursement price will depend entirely on the strength of the data.
To prevent exacerbations and possible hospitalization, patients with severe COPD are treated with inhaled long-acting muscarinic antagonist (LAMA) alone and/or a fixed combination of inhaled corticosteroids/long-acting ?
Upon completion of the transaction, AstraZeneca will own the development and commercial rights in the US and Canada to TudorzaTM PressairTM (aclidinium bromide inhalation powder), a twice-daily long-acting muscarinic antagonist (LAMA) for chronic obstructive pulmonary disease (COPD), and DalirespA (roflumilast), the only once-daily oral PDE4 inhibitor currently on the market for COPD.
The role of three different G-protein coupled receptors (muscarinic, [beta]-adrenergic and purinergic) in the endothelium-dependent relaxation of PA was studied by performing a set of experiments in NE-precontracted aortic rings (E+), previously exposed to the muscarinic antagonist atropine, the [beta]-adrenergic antagonist propranolol and the non-selective P2-purinoceptor antagonist suramin (all at 10 [micro]M).