Analysis of mural cell recruitment to tumor vessels.
As in normal blood vessels, tumor vessels consist of endothelial cells, mural cells (pericytes and smooth muscle cells), and basement membrane (Baluk et al.
Tumor vessels are leaky, immature, or morphologically abnormal because of the absent or incomplete basement membrane and mural cells (pericytes and smooth muscle cells).
Krautler and colleagues isolated pure vascular mural cell populations from fat tissue of mice, which were then introduced into collagen sponges.
One typical marker of mural cells is platelet derived growth factor receptor Beta (PDGFR-Beta).
The recognition that FDCs derive from pluripotent mural cells helps understanding autoimmune and pathogen-driven chronic inflammatory conditions, the generation of FDC-derived tumors, and certain aspects of the pathogenesis of acquired immunodeficiency syndrome (AIDS) and of prion infections.
Recent data from our team and others drew new attention on a discrete population of mesenchymal cells that wraps around vessels, variously called mural cells
, perivascular cells or pericytes, as a major source for profibrotic stromal cells generating scar tissue.