mupirocin


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Related to mupirocin: Bactroban

mupirocin

 [mu-pir´o-sin]
an antibacterial derived from Pseudomonas fluorescens, effective against staphylococci and non-enteric streptococci; used in the treatment of impetigo and, as the calcium salt, in the treatment of nasal colonization by Staphylococcus aureus.

mupirocin (pseudomonic acid, pseudomonic acid A)

Bactroban, Bactroban Nasal 2%, Taro-Mupirocin (CA)

Pharmacologic class: Dermatologic agent

Therapeutic class: Anti-infective, topical

Pregnancy risk category B

Action

Inhibits bacterial protein and RNA synthesis by reversibly and specifically binding to bacterial isoleucyl-transfer RNA synthetase. Bactericidal.

Availability

Intranasal ointment: 2.15%

Topical cream: 2%

Topical ointment: 2%

Indications and dosages

Impetigo

Adults and children ages 2 months to 16 years: Apply a small amount of ointment topically t.i.d. for 3 to 5 days. Reevaluate if no response.

Infected traumatic skin lesions

Adults and children ages 3 months to 16 years: Apply a small amount of cream topically t.i.d. for 10 days.

Nasal colonization of methicillin-resistant Streptococcus aureus

Adults and children ages 12 and older: Apply intranasal ointment (half of single-use tube to each nostril) topically to anterior nares b.i.d. for 5 days.

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:
• moderate or severe renal impairment (with large doses)
• breastfeeding patients
• children younger than age 12 (intranasal ointment), younger than age 3 months (cream), or younger than age 2 months (ointment).

Administration

• After intranasal application, press nares together repeatedly to distribute drug.
• Avoid contact with eyes.
• Discontinue use if sensitization or severe local irritation occurs.
• If desired, cover affected area with gauze dressing after applying cream or ointment.
• Don't use intranasal form with any other nasal spray.
• Don't use Bactroban ointment on mucosal surfaces. Use Bactroban Nasal (mupirocin calcium ointment) intranasally.
• Know that although mupirocin isn't absorbed systemically, polyethylene glycol (its water-miscible ointment base) may be absorbed from open wounds and damaged skin and may be excreted by the kidneys.

Adverse reactions

CNS: headache (with intranasal use)

EENT: rhinitis, nasal stinging or burning, pharyngitis (all with intranasal use)

GI: mouth and lip sores

Skin: pruritus (with intranasal use); dry skin, rash, redness, stinging or pain, secondary wound infection

Other: taste disorders (with intranasal use)

Interactions

None significant

Patient monitoring

• Monitor for drug efficacy.

Patient teaching

• Instruct patient to wash affected area with soap and water and dry it thoroughly, then apply small amount of drug to area and rub in gently. If desired, tell him to apply gauze dressing.
• Advise patient to complete entire course of therapy, even if symptoms disappear. Tell him to try not to miss doses.
• If patient misses a dose, tell him to apply dose as soon as he remembers. However, if it's almost time for next dose, advise him to skip missed dose and resume regular dosing schedule.
• Advise patient to contact prescriber if skin infection doesn't improve within 3 to 5 days or if it worsens.
• Caution patient not to apply drug to eye or mucous membranes (except nasal form for intranasal use).
• As appropriate, review all other significant adverse reactions.

mupirocin

/mu·pir·o·cin/ (mu-pir´o-sin) an antibacterial derived from Pseudomonas fluorescens, effective against staphylococci and non-enteric streptococci; used topically in the treatment of impetigo and, intranasally as the calcium salt, in the treatment of nasal colonization by Staphylococcus aureus.

mupirocin

Dermatology A topical bactericide that inhibits bacterial protein synthesis. See Methicillin-resistant Staphylococcus aureus.

mupirocin

A broad-spectrum antibiotic used externally on the skin and as a nasal ointment to treat carriers of staphylococci. Brand names are Bactroban and Bactroban nasal.

mupirocin

a bacteriostatic antibiotic produced by Pseudomonas fluorescens and used topically, mainly against gram-positive bacteria.
References in periodicals archive ?
Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers.
Cost-effectiveness of preoperative nasal mupirocin treatment in preventing surgical site infection in patients undergoing total hip and knee arthroplasty: a cost-effectiveness analysis.
Antibacterial activity of propolis against MRSA and synergism with topical mupirocin.
Results for erythromycin, fusidic acid and mupirocin are listed for comparison purposes only, with interpretations for fusidic acid and mupirocin taken from EUCAST guidelines.
This concept is emerging through the use of universal barriers (donning gloves, or gowns and gloves, for all patient contact) and universal treatment (daily chlorhexidine bathing and/or intranasal mupirocin application for all patients).
Concurrent workshops included such topics as viewpoints on payment for molecular testing; genetics sendout testing; clinical application of whole genome sequencing; mupirocin resistance in MRSA colonized residents in long-term care facilities; molecular CPT coding structure; anti-viral susceptibility testing; exome and whole genome sequencing; the human microbiome; and a regulatory update on LDTs and companion diagnostics--among many, many other compelling sessions.
aureus inhabits your nasal passages, and if the hospital swabs this area with an anti-microbial product called mupirocin upon admitting you, your risks of developing infection arising from nasal colonization with S.
This shows how mupirocin can be modified to make it more potent and suggests that related molecules could be used against the increasingly problematic Enterobacteriacae," said Prof Thomas, who added that, by using mutant strains, the team was able to feed alternative compounds to the bacteria so a family of novel molecules was created.
This realization led to the adoption of screening protocols to identify carriers prior to admission and then the treatment of those patients with intranasal mupirocin or other agents.
They were treated with either mupirocin ointment twice daily and daily baths with antiseptic chlorhexidine soap or dummy ointment and soap.
Such patients may require mupirocin ointment (Bactroban[R]) or Naseptin[R] ointment twice daily.