multiple endocrine neoplasia


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neoplasia

 [ne″o-pla´zhah]
the formation of a neoplasm.
cervical intraepithelial neoplasia (CIN) dysplasia of the cervical epithelium, often premalignant, characterized by various degrees of hyperplasia, abnormal keratinization, and the presence of condylomata.
multiple endocrine neoplasia (MEN) a group of rare hereditary disorders of autonomous hyperfunction of more than one endocrine gland. In Type I (MEN I), called also Wermer's syndrome, there are tumors of the pituitary, parathyroid gland, and pancreatic islet cells in association with a high incidence of peptic ulcer. Type II (MEN II), called also Sipple's syndrome, is characterized by medullary carcinoma of the thyroid, pheochromocytoma, often bilateral and multiple, and parathyroid hyperplasia. Type III (MEN III), called also mucosal neuroma syndrome, resembles Type II except that parathyroid hyperplasia is rare, the mean survival time is shorter, and there may be neuromas and neurofibromas. All forms are transmitted as autosomal dominant traits.

multiple endocrine neoplasia (MEN),

a group of disorders characterized by functioning tumors in more than one endocrine gland.

multiple endocrine neoplasia (MEN)

a hereditary hormonal disorder that occurs in an autosomal-dominant pattern. The endocrine neoplasms may be expressed as hyperplasia, adenoma, or carcinoma and may develop synchronously or metachronously. Some kinds are multiple mucosal neuroma syndrome, Sipple's syndrome, and Werner's syndrome. See also multiple endocrine neoplasia, type I, and multiple endocrine neoplasia, type II.

multiple endocrine neoplasia, type I

a type of multiple endocrine neoplasia that includes tumors of the pituitary, parathyroid glands, and pancreatic islet cells, often with peptic ulcers and sometimes the Zollinger-Ellison syndrome. See also multiple endocrine neoplasia.

multiple endocrine neoplasia, type II

a type of multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, and hyperplasia of the parathyroid glands. See also multiple endocrine neoplasia.

multiple endocrine neoplasia

See MEN.

mul·ti·ple en·do·crine ne·o·pla·si·a

(MEN) (mŭlti-pĕl endō-krin nēō-plāzē-ă)
A group of disorders characterized by functioning tumors in more than one endocrine gland.

Multiple endocrine neoplasia

Abnormal tissue growth on one or more of the endocrine (hormone-secreting) glands.

mul·ti·ple en·do·crine ne·o·pla·si·a

(MEN) (mŭlti-pĕl endō-krin nēō-plāzē-ă)
Group of disorders characterized by functioning tumors in more than one endocrine gland.
References in periodicals archive ?
Management of multiple endocrine neoplasia syndrome type 2 families in association with rare germline mutations of the RET proto-oncogene.
The clinical significance of such a diagnosis lies mainly in the need of further follow up of these patients as the bowel involvement could be the first manifestation of neurofibromatosis type 1 or multiple endocrine neoplasia type 2b.
Routine measurement of serum calcitonin has been proposed as a cost-effective screen for medullary thyroid carcinoma (11) in individuals at high risk, such as those with a family history of multiple endocrine neoplasia.
MEN-1: Multiple endocrine neoplasia type 1, NECT: Neuroendocrine tumor, GHRH: Growth hormone releasing hormone, GH: Growth hormone, IGF-1: Insulin like growth factor.
2] Nonstandard abbreviations: MEN2, multiple endocrine neoplasia type 2; VHL, von Hippel-Lindau disease; NF1, neurofibromatosis type 1; SDH, succinate dehydrogenase; MN, metanephrine; NMN, normetanephrine; 3MT, 3-methoxytyramine.
He has been centrally involved in discovering genes for conditions that are not exclusive to children, including Huntington's disease, neurofibromatosis, cystic fibrosis, and multiple endocrine neoplasia.
These lesions can be seen in the context of familial syndromes or diseases, including neurofibromatosis, von Hippel-Lindau, Sturge-Weber, tuberous sclerosis and multiple endocrine neoplasia type II.
Primary hyperparathyroidism can be sporadic, familial, or be a component of multiple endocrine neoplasia (MEN) I and Ila.
It is based in part on the booklet Understanding Multiple Endocrine Neoplasia Type 1, published by the NIH Clinical Center's Communications Office.

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