multimer


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multimer

A molecular aggregate held together by noncovalent bonds.
References in periodicals archive ?
Specialised tests, such as vWF multimers and vWF binding to platelets and factor VIII, assist with the sub-classification of vWD.
At high shear stress and when vascular injury occurs, VWF multimer undergoes conformational changes that causes binding to different ligands in the sub-endothelial matrix and promotes platelet adhesion by interaction with the platelet glycoproteins Ib and II b/I IIa (GPIb and GPII b/111 a) receptors (18).
Severe ADAMTS-13 deficiency may result in ultralarge vWF multimers that spontaneously interact with platelet receptors and cause thrombi in microcirculation (14-17).
Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura.
4) Supplementary laboratory testing may also be performed and include VWF multimers, ristocetin induced platelet agglutination (RIPA), and/or VWF-factor VIII binding (VWF:FVIIIB).
M2 EQUITYBITES-January 6, 2017-Momenta partners with CSL for Fc multimer programmes for potential use in autoimmune indications
M2 PHARMA-January 6, 2017-Momenta partners with CSL for Fc multimer programmes for potential use in autoimmune indications
Supplemental VWF multimer analysis identified the absence of high molecular weight VWF multimers, and ristocetin-induced platelet aggregometry demonstrated abnormally increased response to low-dose ristocetin, altogether supporting diagnosis of either type 2B VWD or PT-VWD.
Paraffin oil is a multimer containing multiple ethylene repeating units.
VWF multimer analysis is a qualitative assay that illustrates the variable concentrations of the different-sized VWF multimers by using sodium dodecyl sulphate (SDS)-protein electrophoresis followed by detection of the VWF multimers in the gel, using a radio labelled polyclonal antibody/or a combination of monoclonal antibodies.