ABCC1

(redirected from multidrug resistance-associated protein 1)

ABCC1

A gene on 16p13.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC1 is a transporter of multispecific organic anions, glucuronides and sulfate conjugates of steroid hormones and bile salts; it mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, methotrexate, antivirals and other xenobiotics, and confers resistance to anticancer drugs.
References in periodicals archive ?
The most commonly observed mechanism contributing to MDR is the overexpression of ABC transporters mainly including P-gp, breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in cancer cells (Fenner et al.
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