ABCC3

(redirected from multidrug resistance-associated protein)

ABCC3

A gene on chromosome 17q22 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC3 is thought to play a role in the transport of biliary and intestinal excretion of organic anions.
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The most commonly observed mechanism contributing to MDR is the overexpression of ABC transporters mainly including P-gp, breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in cancer cells (Fenner et al.
Common MDR proteins include permeability related glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance-related protein (LRP) (4), (5).
Relationship between maj or vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression and drug resistance in childhood leukemia.
Two drug pumps commonly found in cancer are P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP).
indicated that DADS has an effect of drug resistance and is able to increase P-glycoprotein and promote the expression of multidrug resistance-associated protein 2 (MRP-2) in vivo (Demeule et al.
ATPase activity of purified multidrug resistance-associated protein.
The gene, which was developed at Queen's University at Kingston, Ontario, Canada, and for which a patent application is pending, expresses a multidrug resistance-associated protein (MRP) that causes cells to become tolerant to otherwise toxic levels of cytotoxic drugs.
A family of drug transporters: the multidrug resistance-associated proteins.
The conjugated drugs are then transported by multidrug resistance-associated proteins (MRP) to the bile for excretion (Borst et al.
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